Histologic correlation of in vivo optical coherence tomography images of the human retina
Histologic correlation of in vivo optical coherence tomography images of the human retina
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DOI：
10.1016/j.ajo.2006.01.086
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发表时间：
2006-06-01
影响因子：
4.2
通讯作者：
de Boer, JF
中科院分区：
文献类型：
--
作者：
Chen, TC;Cense, B;de Boer, JF
目的：将体内人视网膜光学相干断层扫描 (OCT)3 图像与组织学相关联。设计：病例系列。方法：对三名接受眼眶癌摘除手术的患者的三只眼睛进行黄斑和视神经的线性 OCT3 扫描。然后将 OCT3 图像与组织学相关联。结果：组织学上，两只眼睛正常，一只眼睛患有干性黄斑变性。组织学上的丛状层与 OCT3 扫描上的绿色/黄色区域相关，核层与 OCT3 扫描上的黑色区域相关。 结论：作者不知道以前将组织学与体内人类视网膜 OCT3 图像相关联的报道。我们使用人眼的发现与之前的动物研究没有什么不同，因为丛状层在光学上具有高度反向散射，而核层则不然。
PURPOSE: To correlate in vivo human retina optical coherence tomography (OCT)3 images with histology.DESIGN: Case series.METHODS: Linear OCT3 scans through the macula and optic nerve were obtained in three eyes of three patients who then underwent exenteration surgery for orbital cancers. OCT3 images were then correlated with histology.RESULTS: On histology, two eyes were normal, and one eye had dry macular degeneration. The plexiform layers on histology correlated with the green/yellow areas on the OCT3 scans, and the nuclear layers correlated with the black areas on the OCT3 scans.CONCLUSIONS: The authors are unaware of previous reports correlating histology to in vivo human retina OCT3 images. Our findings using human eyes are not different from previous animal studies, in that the plexiform layers are optically highly backscattering and the nuclear layers are not.