Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo.
Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo.
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DOI：
10.1039/c6cc02848a
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发表时间：
2016-05
影响因子：
4.9
通讯作者：
Xiupeng Wang;Xia Li;A. Ito;Yohei Watanabe;N. Tsuji
中科院分区：
文献类型：
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作者：
Xiupeng Wang;Xia Li;A. Ito;Yohei Watanabe;N. Tsuji
本论文采用水热法制备了棒状含氟羟基磷灰石纳米颗粒(FHA)。棒状FHA在体外能显著增加骨髓树突状细胞对模型抗原的摄取，改善体内抗原提呈，刺激免疫相关细胞因子的分泌，增强体内抗癌免疫。
Herein, rod-shaped and fluorine-substituted hydroxyapatite nanoparticles (FHA) were synthesized using a facile hydrothermal method. The rod-shaped FHA significantly increased the cellular uptake of a model antigen by bone marrow dentritic cells in vitro, improved antigen presentation in vivo, stimulated immune-related cytokine secretion in vitro and ex vivo, and enhanced the anti-cancer immunity in vivo.