Low-Intensity Focused Ultrasound Modulates Monkey Visuomotor Behavior
Low-Intensity Focused Ultrasound Modulates Monkey Visuomotor Behavior
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DOI：
10.1016/j.cub.2013.10.029
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发表时间：
2013-12-02
期刊：
影响因子：
9.2
通讯作者：
Aubry, Jean-Francois
中科院分区：
文献类型：
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作者：
Deffieux, Thomas;Younan, Youliana;Aubry, Jean-Francois
最近在麻醉兔形目动物[1]和啮齿动物[2-4]中测试了使用低强度聚焦超声（FUS）瞬时调节局部脑组织功能的体内可行性。假设，超声波刺激大脑具有几个优点[5]：它不需要手术或基因改变，但最终可以赋予空间分辨率上级于其他非侵入性方法。在这里，我们衡量了非侵入性FUS因果调节高级认知行为的能力。因此，我们研究了如何FUS可能会干扰前额叶活动在两个清醒的猕猴，已被训练执行antisaccade（AS）的任务。我们发现，超声显着调制AS乳酸。这种影响被证明是依赖于FUS半场的刺激（相对潜伏期增加最同侧AS）。这些结果被解释在调制眼跳抑制对侧视野，由于整个额叶眼场的处理中断。我们的研究首次证明了使用FUS刺激在清醒的非人灵长类动物大脑中因果调节行为的可行性。这一结果支持使用这种方法来研究大脑功能。超声神经刺激可用于非侵入性的探索和治疗目的，具有潜在的前所未有的空间分辨率。
In vivo feasibility of using low-intensity focused ultrasound (FUS) to transiently modulate the function of regional brain tissue has been recently tested in anesthetized lagomorphs [1] and rodents [2-4]. Hypothetically, ultrasonic stimulation of the brain possesses several advantages [5]: it does not necessitate surgery or genetic alteration but could ultimately confer spatial resolutions superior to other noninvasive methods. Here, we gauged the ability of noninvasive FUS to causally modulate high-level cognitive behavior. Therefore, we examined how FUS might interfere with prefrontal activity in two awake macaque rhesus monkeys that had been trained to perform an antisaccade (AS) task. We show that ultrasound significantly modulated AS latencies. Such effects proved to be dependent on FUS hemifield of stimulation (relative latency increases most for ipsilateral AS). These results are interpreted in terms of a modulation of saccade inhibition to the contralateral visual field due to the disruption of processing across the frontal eye fields. Our study demonstrates for the first time the feasibility of using FUS stimulation to causally modulate behavior in the awake nonhuman primate brain. This result supports the use of this approach to study brain function. Neurostimulation with ultrasound could be used for exploratory and therapeutic purposes noninvasively, with potentially unprecedented spatial resolution.