Epigenetics and pesticides
Epigenetics and pesticides
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DOI：
10.1016/j.tox.2013.01.017
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发表时间：
2013-05-10
期刊：
影响因子：
4.5
通讯作者：
Bollati, V.
中科院分区：
文献类型：
--
作者：
Collotta, M.;Bertazzi, P. A.;Bollati, V.
农药是一类广泛的环境污染物，可能对接触农药的受试者造成急性和延迟的健康影响。这些影响可以从简单的皮肤和眼睛刺激到更严重的影响，如影响神经系统，生殖系统和癌症。表观遗传学是研究基因表达的可遗传变化，而这些变化是在DNA序列没有改变的情况下发生的。一些表观遗传机制，包括DNA甲基化，组蛋白修饰和microRNA表达，可以由环境因素触发。我们回顾了目前的证据，表明表观遗传修饰可能介导农药对人类健康的影响。体外、动物和人类研究已经确定了几类修饰表观遗传标记的农药，包括内分泌干扰物、持久性有机污染物、砷、几种除草剂和杀虫剂。一些调查研究了环境暴露和表观遗传标记的影响，并确定了改变表观遗传状态的有毒物质。这些修饰与病理组织样品中发现的修饰相似。尽管目前的局限性，现有的证据支持的概念，表观遗传学具有很大的潜力，进一步了解农药的健康影响的分子机制，以及预测与健康有关的风险，由于环境暴露条件和个人的易感性。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Pesticides, a wide class of environmental contaminants, may cause both acute and delayed health effects in exposed subjects. These effects can range from simple irritation of the skin and eyes to more severe effects such as affecting the nervous system, the reproductive system and cancer. The molecular mechanisms underlying such effects are still under investigation.Epigenetics is the study of heritable changes in gene expression that occur without a change in the DNA sequence. Several epigenetic mechanisms, including DNA methylation, histone modifications and microRNA expression, can be triggered by environmental factors. We review current evidences indicating that epigenetic modifications may mediate pesticide effects on human health.In vitro, animal, and human investigations have identified several classes of pesticides that modify epigenetic marks, including endocrine disruptors, persistent organic pollutants, arsenic, several herbicides and insecticides.Several investigations have examined the effects of environmental exposures and epigenetic markers, and identified toxicants that modify epigenetic states. These modifications are similar to the ones found in pathological tissue samples. In spite of the current limitations, available evidence supports the concept that epigenetics holds substantial potential for furthering our understanding of the molecular mechanisms of pesticides health effects, as well as for predicting health-related risks due to conditions of environmental exposure and individual susceptibility. (C) 2013 Elsevier Ireland Ltd. All rights reserved.