Traditional Herbal Medicine Prevents Postoperative Recurrence of Small Hepatocellular Carcinoma: A Randomized Controlled Study
Traditional Herbal Medicine Prevents Postoperative Recurrence of Small Hepatocellular Carcinoma: A Randomized Controlled Study
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传统草药预防小肝细胞癌术后复发：一项随机对照研究
DOI：
10.1002/cncr.30915
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发表时间：
2018-05-15
期刊：
影响因子：
6.2
通讯作者：
Ling, Chang-quan
中科院分区：
文献类型：
--
作者：
Zhai, Xiao-feng;Liu, Xiao-lin;Ling, Chang-quan
背景技术背景：为探讨中药预防小肝癌术后复发的临床疗效，于2006年10月至2010年5月进行了一项前瞻性随机对照研究。结果表明，在中位随访26.61个月期间，THM预防小肝癌复发的疗效上级优于经动脉化疗栓塞（TACE）。方法：每6个月随访一次，分析2015年10月20日前的临床资料。主要结局指标为无复发生存期（RFS），次要结局指标为总生存期（OS）。结果：364例患者包括THM组180例和TACE组184例。截至数据截止日期2015年10月20日，共有205例患者出现疾病复发，其中THM组85例，TACE组120例。THM组和TACE组的RFS中位数存在统计学显著差异（P <0.001）。截至2105年10月20日，共有91例死亡，其中THM组34例，TACE组57例。两组的中位OS存在显著差异（P = .008）。多变量分析表明，THM是影响RFS和OS的独立因素。结论：THM在预防小肝癌患者疾病复发和延长OS方面的疗效上级TACE。（C）2018年美国癌症协会。
BACKGROUND: To explore the clinical efficacy of traditional herbal medicine (THM) in the prevention of disease recurrence of small hepatocellular carcinoma after surgery, a prospective randomized controlled study was conducted between October 2006 and May 2010. The results indicated that THM prevented the recurrence of SHCC with an efficacy that was superior to that of transarterial chemoembolization (TACE) during a median follow-up of 26.61 months. METHODS: The patients were followed up every 6 months, and the clinical data before October 20, 2015 were analyzed. The primary outcome measure was recurrence-free survival (RFS), and the secondary outcome measure was overall survival (OS). RESULTS: The 364 patients included 180 in the THM group and 184 in the TACE group. At the time of the data cutoff of October 20, 2015, a total of 205 patients demonstrated disease recurrence, including 85 patients in the THM group and 120 patients in the TACE group. The median RFS of the THM and TACE groups demonstrated a statistically significant difference (P < .001). Until October 20, 2105, there were 91 deaths, including 34 in the THM group and 57 in the TACE group. The median OS demonstrated a significant difference between the 2 groups (P = .008). Multivariate analysis indicated that THM was an independent factor influencing RFS and OS. CONCLUSIONS: The efficacy of THM was found to be superior to that of TACE in preventing disease recurrence in patients with small hepatocellular carcinoma and prolonging OS. (C) 2018 American Cancer Society.