A meta-analysis of sex differences in human brain structure
A meta-analysis of sex differences in human brain structure
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DOI：
10.1016/j.neubiorev.2013.12.004
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发表时间：
2014-02-01
影响因子：
8.2
通讯作者：
Suckling, John
中科院分区：
文献类型：
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作者：
Ruigrok, Amber N. V.;Salimi-Khorshidi, Gholaihreza;Suckling, John
许多神经精神疾病的患病率、发病年龄和症状在男性和女性之间有所不同。为了了解性别差异的原因和后果，重要的是要确定它们在人脑中发生的位置。我们报告了对全球大脑体积的典型性别差异的首次荟萃分析，按六个年龄组对每个区室体积的研究进行了描述性分析，以及对脑体积和密度的全脑体素荟萃分析。使用基于高斯过程回归坐标的荟萃分析来检查基于体素的区域体积和密度的性别差异。平均而言，男性的大脑总体积比女性大。对按年龄类别提供总数量的研究细分进行的检查表明，偏向于 18-59 岁类别。体积和组织密度的区域性别差异包括杏仁核、海马体和岛叶，这些区域已知与性别偏见的神经精神疾病有关。总之，这些结果为研究性别对发育中的大脑的不对称影响以及了解性别偏见的神经和精神疾病提供了候选区域。 (C) 2014 年作者。由爱思唯尔有限公司出版。保留所有权利。
The prevalence, age of onset, and symptomatology of many neuropsychiatric conditions differ between males and females. To understand the causes and consequences of sex differences it is important to establish where they occur in the human brain. We report the first meta-analysis of typical sex differences on global brain volume, a descriptive account of the breakdown of studies of each compartmental volume by six age categories, and whole-brain voxel-wise meta-analyses on brain volume and density. Gaussian-process regression coordinate-based meta-analysis was used to examine sex differences in voxel-based regional volume and density. On average, males have larger total brain volumes than females. Examination of the breakdown of studies providing total volumes by age categories indicated a bias towards the 18-59 year-old category. Regional sex differences in volume and tissue density include the amygdala, hippocampus and insula, areas known to be implicated in sex-biased neuropsychiatric conditions. Together, these results suggest candidate regions for investigating the asymmetric effect that sex has on the developing brain, and for understanding sex-biased neurological and psychiatric conditions. (C) 2014 The Authors. Published by Elsevier Ltd. All rights reserved.