Dietary fat and risk for advanced age-related macular degeneration
Dietary fat and risk for advanced age-related macular degeneration
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DOI：
10.1001/archopht.119.8.1191
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发表时间：
2001-08-01
影响因子：
--
通讯作者：
Willett, W
中科院分区：
文献类型：
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作者：
Seddon, JM;Rosner, B;Willett, W
目的：评估总脂肪和特定类型脂肪的摄入量与晚期年龄相关性黄斑变性（AMD）风险之间的关系，AMD是成人不可逆性失明的主要原因。设计：一项多中心眼病病例对照研究。病例研究对象包括349名个体（年龄范围，55-80岁），在入组研究后1年内诊断为AMD的新生血管期，居住在参与临床中心附近。对照受试者包括504名没有AMD但患有其他眼部疾病的个体。对照组来自相同的地理区域的情况下，频率匹配的情况下，年龄和sex.Main结果措施：相对风险AMD根据水平的脂肪摄入量，控制吸烟和其他riskfactors.Results：较高的植物脂肪消费量与AMD的风险升高。在调整了年龄、性别、教育、吸烟和其他危险因素后，摄入量最高的人与摄入量最低的人的比值比（OR）为2.22（95%置信区间[ CI] 1.32-3.74）（趋势P为0.007）。单不饱和脂肪（OR，1.71）和多不饱和脂肪（OR，1.86）摄入量最高与最低五分位数相比，AMD的风险也显著升高（趋势P分别为0.03和0.03）。亚油酸的高消耗量也与AMD的高风险相关（趋势P，0.02）。在摄入低亚油酸（一种omega-6脂肪酸）的个体中，摄入较高的omega-3脂肪酸与AMD风险降低相关（趋势P，0.05;连续变量P，0.03）。同样，当饮食中亚油酸含量低时，较高频率的鱼类摄入倾向于降低AMD的风险（趋势P，0.05）。相反，无论是欧米茄-3脂肪酸，也没有鱼的摄入量与风险AMD的人与高水平的亚油酸initiation.Conclusion：更高的摄入量的特定类型的脂肪，包括蔬菜，单不饱和脂肪，多不饱和脂肪和亚油酸，而不是总的脂肪摄入量可能与更大的风险先进的AMD。当亚油酸摄入量较低时，高ω-3脂肪酸和鱼类的饮食与AMD的风险呈负相关。
Objective: To evaluate the relationship between intake of total and specific types of fat and risk for advanced age-related macular degeneration (AMD), the leading cause of irreversible blindness in adults.Design: A multicenter eye disease case-control studySetting: Five US clinical ophthalmology centers.Patients: Case subjects included 349 individuals (age range, 55-80 years) with the advanced, neovascular stage of AMD diagnosed within 1 year of their enrollment into the study who resided near a participating clinical center. Control subjects included 504 individuals without AMD but with other ocular diseases. Controls were from the same geographic areas as cases and were frequency-matched to cases by age and sex.Main Outcome Measures: Relative risk for AMD according to level of fat intake, controlling for cigarette smoking and other risk factors.Results: Higher vegetable fat consumption was associated with an elevated risk for AMD. After adjusting for age, sex, education, cigarette smoking, and other risk factors, the odds ratio (OR) was 2.22 (95% confidence interval [ CI] 1.32-3.74) for persons in the highest vs those in the lowest quintiles of intake (P for trend, .007). The risk for AMD was also significantly elevated for the highest vs lowest quintiles of intake of monounsaturated (OR, 1.71) and polyunsaturated (OR, 1.86) fats (Ps for trend, .03 and .03, respectively). Higher consumption of linoleic acid was also associated with a higher risk for AMD (P for trend, .02). Higher intake of omega -3 fatty acids was associated with a lower risk for AMD among individuals consuming diets low in linoleic acid, an omega -6 fatty acid (P for trend, .05; P for continuous variable,.03). Similarly, higher frequency of fish intake tended to reduce risk for AMD when the diet was low in linoleic acid (P for trend, .05). Conversely, neither omega -3 fatty acids nor fish intake were related to risk for AMD among people with high levels of linoleic acid intake.Conclusion: Higher intake of specific types of fat-including vegetable, monounsaturated, and polyunsaturated fats and linoleic acid-rather than total fat intake may be associated with a greater risk for advanced AMD. Diets high in omega -3 fatty acids and fish were inversely associated with risk for AMD when intake of linoleic acid was low.