The effect of alcohol use on IL-6 responses across different racial/ethnic groups.
The effect of alcohol use on IL-6 responses across different racial/ethnic groups.
复制标题
DOI：
10.2217/fvl.12.3
复制
发表时间：
2012-02
期刊：
影响因子：
3.1
通讯作者：
Malow R
中科院分区：
文献类型：
--
作者：
Míguez MJ;Rosenberg R;Burbano-Levy X;Carmona T;Malow R
鉴于慢性炎症与多种疾病的关系，慢性炎症已越来越被认为是对艾滋病毒携带者的健康威胁。因此，科学界已将确定引发炎症的机制列为优先事项。一项以临床为基础的病例对照研究旨在阐明饮酒对IL-6的可能影响。采集59例酒精中毒患者和66例非酒精中毒患者的外周血单个核细胞，根据年龄、性别和美国疾病控制与预防中心的HIV严重程度进行配对，分别检测IL-6培养上清液和血浆进行HIV检测。与非危险酒精使用者相比，危险酒精使用者受刺激的外周血单核细胞产生的IL-6显著增加。然而，种族地位和接受HAART显著缓和了这种影响。值得注意的是，在HAART和非HAART方案中，IL-6水平与CD4计数和病毒载量有关。各种族/民族之间独特的IL-6产生模式也很明显，表明在处方HAART时，西班牙裔危险酒精使用者与他们的高加索人和非裔美国人相比，发病风险特别高。在调整了混杂因素(例如，社会人口学和艾滋病毒疾病状况)后，回归分析证实，IL-6水平(LOG)表明的慢性炎症与饮酒、种族/民族和血小板减少有关，并往往与同时吸烟有关。我们的数据证实，尽管进行了HAART，艾滋病毒携带者仍然有持续的炎症反应，在我们的研究中，这与慢性危险酒精使用有关。这些数据还突显了IL-6的种族/民族差异，这证明了进一步调查的合理性。
Chronic inflammation has become increasingly recognized as a health threat for people living with HIV, given its associations with multiple diseases. Accordingly, the scientific community has prioritized the need to identify mechanisms triggering inflammation. A clinic-based case–control study was designed to elucidate the plausible effects of alcohol use on IL-6. Peripheral blood mononuclear cells for measuring IL-6 culture supernatant and plasma for HIV assessments were collected from 59 hazardous alcohol users and 66 nonhazardous alcohol users, who were matched according to their age, gender and US CDC HIV severity status. Stimulated peripheral blood mononuclear cells produced significantly higher amounts of IL-6 in hazardous alcohol users compared with nonhazardous alcohol users. However, racial status and receiving HAART significantly moderated this effect. Notably, in both HAART and non-HAART scenarios, IL-6 levels were associated with CD4 counts and viral burden. A distinctive IL-6 production pattern across racial/ethnic groups was also evident and showed that, when prescribed HAART, Hispanic hazardous alcohol users have a particularly high risk of morbidity compared with their Caucasian and African–American counterparts. After adjusting for confounders (e.g., sociodemographics and HIV disease status), regression analyses confirmed that chronic inflammation, as indicated by IL-6 levels (log), is associated with alcohol use, race/ethnicity and thrombocytopenia, and tended to be related to concurrent smoking. Our data confirm that, despite HAART, people living with HIV still have a persistent inflammatory response that, in our study, was associated with chronic hazardous alcohol use. The data also highlight racial/ethnic disparities in IL-6 that justify further investigations.