Plasticity in the maternal circuit: Effects of experience and partum condition on brain astrocyte number in female rats
Plasticity in the maternal circuit: Effects of experience and partum condition on brain astrocyte number in female rats
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DOI：
10.1037/0735-7044.114.1.158
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发表时间：
2000-02-01
影响因子：
1.9
通讯作者：
Ivy, GO
中科院分区：
文献类型：
--
作者：
Featherstone, RE;Fleming, AS;Ivy, GO
接受过母性经历的雌性大鼠在再次接触幼崽时，大脑多个部位的 c-fos 表达会增强。目前的两项研究检查了另一种脑蛋白——神经胶质纤维酸性蛋白（GFAP）——星形胶质细胞骨架的主要单位——表达的变化。在这两项实验中，初产和经产的雌性大鼠在产后与幼鼠进行了不同程度的接触，并在不同的时间间隔后过量服用，没有幼鼠。准备大脑用于 GFAP 免疫组织化学分析。在这两项研究中，与暴露于幼崽的初产受试者相比，产后第 5 天的多产受试者在产后与幼崽进行了额外的接触，发现下丘脑内侧视前区（该区域对于母体行为表达至关重要）中的 GFAP 阳性细胞数量显着增加，但在对照部位却没有。在实验2中，在内侧杏仁核和缰核中发现了奇偶性的相反效果。
Female rats that have received a maternal experience undergo enhanced c-fos expression in a number of brain sites when reexposed to pups. The present 2 studies examined changes in the expression of another brain protein, glial fibrillary acidic protein (GFAP), which is a major unit of the astrocytic cytoskeleton. In both experiments, primiparous and multiparous female rats were given varying amounts of postpartum contact with pups and overdosed after varying intervals, with no pups. Brains were prepared for GFAP immunohistochemical analysis. In both studies, Day 5 postpartum multiparous subjects given additional postpartum contact with pups, when compared with pup-exposed primiparous subjects, were found to have significantly higher numbers of GFAP positive cells in the medial preoptic area of the hypothalamus, an area critical for the expression of maternal behavior, but not in control sites. In Experiment 2, an opposite effect of parity was found in the medial amygdala and habenula.