The effect of claustrum lesions on human consciousness and recovery of function
The effect of claustrum lesions on human consciousness and recovery of function
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DOI：
10.1016/j.concog.2015.06.017
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发表时间：
2015-11-01
影响因子：
2.4
通讯作者：
Grafman, Jordan
中科院分区：
文献类型：
--
作者：
Chau, Aileen;Salazar, Andres M.;Grafman, Jordan
克里克和科赫提出屏状体在意识中起着至关重要的作用。他们的建议是基于屏状体的结构和连通性，表明它在协调一系列不同的大脑功能方面发挥作用。鉴于对这一说法进行调查的人类研究很少，我们决定研究171名患有穿透性创伤性脑损伤的退伍军人的屏状核损伤对意识的影响。此外，我们还研究了屏状核病变和意识丧失对长期认知能力的影响。屏状体损伤与意识丧失的持续时间有关，但与频率无关，这表明屏状体可能在恢复意识方面发挥重要作用，而不是维持意识。总的脑容量损失与神经行为功能的长期恢复有关，但与屏状核病变无关。我们的发现限制了目前对屏状体的神经行为功能及其在维持和恢复意识中的作用的理解。(C) 2015爱思唯尔公司版权所有。
Crick and Koch proposed that the claustrum plays a crucial role in consciousness. Their proposal was based on the structure and connectivity of the claustrum that suggested it had a role in coordinating a set of diverse brain functions. Given the few human studies investigating this claim, we decided to study the effects of claustrum lesions on consciousness in 171 combat veterans with penetrating traumatic brain injuries. Additionally, we studied the effects of claustrum lesions and loss of consciousness on long-term cognitive abilities. Claustrum damage was associated with the duration, but not frequency, of loss of consciousness, indicating that the claustrum may have an important role in regaining, but not maintaining, consciousness. Total brain volume loss, but not claustrum lesions, was associated with long-term recovery of neurobehavioral functions. Our findings constrain the current understanding of the neurobehavioral functions of the claustrum and its role in maintaining and regaining consciousness. (C) 2015 Elsevier Inc. All rights reserved.