Bioaccumulation of pharmaceuticals and personal care products in the unionid mussel Lasmigona costata in a river receiving wastewater effluent
Bioaccumulation of pharmaceuticals and personal care products in the unionid mussel Lasmigona costata in a river receiving wastewater effluent
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DOI：
10.1016/j.chemosphere.2015.12.022
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发表时间：
2016-03-01
期刊：
影响因子：
8.8
通讯作者：
Gillis, P. L.
中科院分区：
文献类型：
--
作者：
de Solla, S. R.;Gilroy, E. A. M.;Gillis, P. L.
淡水贻贝经常出现在接收污水处理厂（WWTP）流出物的河流中，有强有力的证据表明，水质差对淡水贻贝种群有害。污水处理厂是地表沃茨中药品和个人护理产品（PPCP）的主要来源之一。我们监测了145 PPCPs野生和笼贻贝的上游和下游的基奇纳污水处理厂在格兰德河，安大略，以及118 PPCPs的水样。我们的目标是表征水中PPCP浓度的季节性变化，计算贻贝中PPCPs的生物累积因子（BAF），并确定PPCPs驱动生物累积的化学和物理性质。在水中检测到70种PPCPs，浓度在夏季或初秋最高，这与河流流量低相对应。在贻贝组织中检测到来自许多药物类别的43种PPCPs，包括兴奋剂、造影剂、抗炎药、抗菌剂、抗生素、抗抑郁药、抗组胺药、孕激素和非法药物如可卡因和安非他明。BAF范围从二甲双胍的0.66到舍曲林的32022。使用偏最小二乘法根据化学特性、log K-OC、Log K-OW和逸度比（沉积物）预测生物累积系数，所有这些都具有与生物累积系数相似的正负荷（（RX）-X-2 = 0.70;笼中贻贝）。贻贝中PPCPs的生物累积系数可通过逸度模型预测，逸度模型使用log K-OW估算生物浓缩系数。我们的研究表明，贻贝很容易生物积累PPCPs，与基于BCF模型和每种化合物的化学特性的预期一致。皇冠版权所有（C）2015由爱思唯尔有限公司出版。保留所有权利。
Freshwater mussels are frequently found in rivers receiving effluent from wastewater treatment plants (WWTP), and there is strong evidence that poor water quality is deleterious to freshwater mussel populations. WWTPs are among the main sources of pharmaceuticals and personal care products (PPCPs) in surface waters. We monitored 145 PPCPs in wild and caged mussels both upstream and downstream of the Kitchener WWTP in the Grand River, Ontario, as well as 118 PPCPs in water samples. Our objectives were to characterize the seasonal changes in PPCP concentrations in water, to calculate bioaccumulation factors (BAFs) of PPCPs in mussels, and to determine the chemical and physical properties of PPCPs driving the bioaccumulation. Seventy PPCPs were detected in water, and concentrations were highest in the summer or early fall, which corresponded to low river flow. Forty-three PPCPs from many pharmaceutical classes were detected in mussel tissues, including stimulants, a contrasting agent, anti-inflammatory drugs, anti-bacterial agents, antibiotics, antidepressants, antihistamines, progestins, and illicit drugs such as cocaine and amphetamines. The BAFs ranged from 0.66 for metformin to 32 022 for sertraline. Using partial least squares to predict BAFs based upon chemical properties, log K-OC, Log K-OW, and fugacity ratio (sediment) all had similar and positive loadings with BAFs ((RX)-X-2 = 0.70; caged mussels). BAFs of PPCPs in mussels were predictable from fugacity models that estimate bioconcentration factors using log K-OW. Our study demonstrated that mussels readily bioaccumulate PPCPs, in a manner consistent with expectations based upon BCF models and the chemical characteristics of each compound. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.