Predictors of quality of life in newly diagnosed melanoma and breast cancer patients
Predictors of quality of life in newly diagnosed melanoma and breast cancer patients
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DOI：
10.1093/annonc/mdi146
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发表时间：
2005-05-01
影响因子：
50.5
通讯作者：
Kellokumpu-Lehtinen, P
中科院分区：
文献类型：
--
作者：
Lehto, US;Ojanen, M;Kellokumpu-Lehtinen, P
背景：生活质量（QoL）是一个多维度的结构，一些心理和医学因素可以预测患者的QoL。我们调查了诊断为黑色素瘤或乳腺癌后3个月心理应激过程中的因素对生活质量的影响。在连续的黑色素瘤和乳腺癌患者的局限性疾病，癌症特异性社会支持，应对癌症，人格特质愤怒表达，非癌症压力，社会人口学变量，癌症和治疗变量和生活质量（评价为自我报告的心理和身体症状，自我感知的生活质量，抑郁）进行了评估，验证定量问卷。生活质量和其他因素之间的关联进行了调查与多变量methods.Results：只有少数因素不同黑色素瘤和乳腺癌，在治疗方式和性别。乳腺癌患者获得的社会支持量较高。心理压力因素对所有生活质量指标的预测能力很强，但治疗组之间存在差异（仅手术与辅助治疗）。心理社会因素是生活质量的最强预测因子，而不是癌症类型或治疗。行为逃避-回避应对与较差的生活质量相关。然而，非癌症的生活压力表现出最强的生活质量下降的影响。包括社会支持在内的生活质量增强因素仅在接受辅助治疗的乳腺癌患者中明显可见。结论：新诊断癌症患者的生活质量与心理社会因素高度相关。非癌症的生活压力似乎是非常重要的生活质量的新诊断的癌症患者。辅助治疗可能包括支持性心理社会因素，提高癌症的生活质量。
Background: Quality of life (QoL) is a multidimensional construct, and several psychosocial and medical factors can predict a patient's QoL. We investigated the impact of factors in the psychological stress processes on QoL 3 months after diagnosis of melanoma or breast cancer.Patients and methods: In consecutive melanoma and breast cancer patients with localized disease, cancer-specific social support, coping with cancer, personality trait anger expression, non-cancer stress, sociodemographic variables, cancer and treatment variables, and QoL (evaluated as self-reported psychological and physical symptoms, self-perceived QoL, and depression) were assessed with validated quantitative questionnaires. The associations between QoL and the other factors were investigated with multivariate methods.Results: Only a few factors differed between melanoma and breast cancer, in terms of treatment modalities and gender. The amount of received social support was higher among breast cancer patients. The predicting power of psychological stress factors on all the QoL measures was strong, but differed between the treatment groups (surgery only versus adjuvant treatment). Psychosocial factors were the strongest predictors of QoL, not cancer type or treatment. Behavioral Escape-Avoidance coping was associated with worse QoL. However, non-cancer life stresses showed the strongest QoL-decreasing influence. QoL-enhancing factors, including social support, were seen clearly only within the breast cancer patients receiving adjuvant treatment.Conclusions: QoL of newly diagnosed cancer patients is highly associated with psychosocial factors. Non-cancer life stresses seem to be very important in the QoL of newly diagnosed cancer patients. Adjuvant treatment may comprise supportive psychosocial factors that enhance QoL in cancer.