A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.
A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.
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DOI：
10.1056/nejm200011023431802
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发表时间：
2000-11-02
影响因子：
158.5
通讯作者：
Bigelow, GE
中科院分区：
文献类型：
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作者：
Johnson, RE;Chutuape, MA;Bigelow, GE
背景资料：阿片类药物依赖是一种慢性，复发性疾病，具有重要的公共卫生implications.Methods：在一项为期17周的随机研究220例，我们比较了醋酸左美沙酯（75至115毫克），丁丙诺啡（16至32毫克），高剂量（60至100毫克）和低剂量（20毫克）美沙酮作为阿片类药物依赖的治疗。醋酸左美沙酮和丁丙诺啡每周给药三次。每天给予美沙酮。除了低剂量美沙酮组外，剂量均个体化。结果：每组有55名患者，51%的患者完成了试验。接受醋酸左美沙酮（89+/-6）、丁丙诺啡（96+/-4）和高剂量美沙酮（105+/-4）的患者留在研究中的平均（+/-SE）天数显著高于接受低剂量美沙酮的患者（70+/-4，P
Background: Opioid dependence is a chronic, relapsing disorder with important public health implications.Methods: In a 17-week randomized study of 220 patients, we compared levomethadyl acetate (75 to 115 mg), buprenorphine (16 to 32 mg), and high-dose (60 to 100 mg) and low-dose (20 mg) methadone as treatments for opioid dependence. Levomethadyl acetate and buprenorphine were administered three times a week. Methadone was administered daily. Doses were individualized except in the group assigned to low-dose methadone. Patients with poor responses to treatment were switched to methadone.Results: There were 55 patients in each group; 51 percent completed the trial. The mean (+/-SE) number of days that a patient remained in the study was significantly higher for those receiving levomethadyl acetate (89+/-6), buprenorphine (96+/-4), and high-dose methadone (105+/-4) than for those receiving low-dose methadone (70+/-4, P