Physiological processes non-linearly affect electrophysiological recordings during transcranial electric stimulation
Physiological processes non-linearly affect electrophysiological recordings during transcranial electric stimulation
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DOI：
10.1016/j.neuroimage.2016.03.065
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发表时间：
2016-10-01
期刊：
影响因子：
5.7
通讯作者：
Siegel, Markus
中科院分区：
文献类型：
--
作者：
Noury, Nima;Hipp, Joerg F.;Siegel, Markus
经颅电刺激(TES)是一种很有前途的非侵入性操作人脑神经元活动的工具。几项研究已经显示了TES的行为影响，但刺激伪影使同时研究脑电或脑磁图的神经活动变得复杂。这里，我们首先针对脑电和脑磁图显示，与先前的假设相反，伪影并不简单地反映刺激电流，而是心跳和呼吸非线性调制刺激伪影。这些调制与刺激频率无关，即在经颅交流刺激和直流电刺激(TAC和TDC)期间发生。第二，我们证明了，尽管乍一看以前使用的伪像拒绝方法似乎去除了伪像，但数据仍然受到非线性刺激伪像的污染。由于它们的复杂性和对受试者生理状态的依赖，这些伪影很容易被误认为神经缠绕。总之，我们的结果揭示了非线性TES伪影，表明现有技术无法完全去除它们，并为新的伪影抑制方法铺平了道路。(C)2016 Elsevier Inc.保留所有权利。
Transcranial electric stimulation (tES) is a promising tool to non-invasively manipulate neuronal activity in the human brain. Several studies have shown behavioral effects of tES, but stimulation artifacts complicate the simultaneous investigation of neural activity with EEG or MEG. Here, we first show for EEG and MEG, that contrary to previous assumptions, artifacts do not simply reflect stimulation currents, but that heartbeat and respiration non-linearly modulate stimulation artifacts. These modulations occur irrespective of the stimulation frequency, i.e. during both transcranial alternating and direct current stimulations (tACS and tDCS). Second, we show that, although at first sight previously employed artifact rejection methods may seem to remove artifacts, data are still contaminated by non-linear stimulation artifacts. Because of their complex nature and dependence on the subjects' physiological state, these artifacts are prone to be mistaken as neural entrainment. In sum, our results uncover non-linear tES artifacts, show that current techniques fail to fully remove them, and pave the way for new artifact rejection methods. (C) 2016 Elsevier Inc. All rights reserved.