Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma
Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma
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DOI：
10.1007/s00432-022-04078-y
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发表时间：
2022-06-23
影响因子：
3.6
通讯作者：
Oda, Yoshinao
中科院分区：
文献类型：
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作者：
Ishihara, Shin;Iwasaki, Takeshi;Oda, Yoshinao
目的未分化多形性肉瘤（Undifferentiated pleomorphic sarcoma， UPS）预后差。近年来，作为巨噬细胞免疫检查点的信号调节蛋白α (SIRP α)和作为T细胞和自然杀伤细胞免疫检查点的具有免疫球蛋白和酪氨酸基抑制基序域的T细胞免疫受体（TIGIT）被认为是癌症免疫治疗的潜在靶点。本研究旨在评估SIRP α和TIGIT作为UPS预后因素的价值。材料与方法利用cBio Cancer Genomics Portal对50例UPS患者的Cancer Genome Atlas中的mRNA表达数据进行分析。我们检索了49例UPS病例，并进行免疫组织化学（IHC）检测程序性死亡配体1 （PD-L1）、SIRP α、CD68、CD163、TIGIT、CD155和CD8。结果SIRP α与CD163呈正相关（Pearson’s r = 0.51, p = 0）。根据开放获取数据和队列IHC (p = 0.002)，这表明SIRP α阳性巨噬细胞浸润在>= 1% PD-L1表达的UPS细胞中高于在>= 1% PD-L1表达的UPS细胞
Purpose Undifferentiated pleomorphic sarcoma (UPS) is associated with poor prognosis. Recently, signal regulatory protein alpha (SIRP alpha), which is the immune checkpoint of macrophages, and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), which is the immune checkpoint of T cells and natural killer cells, have been considered as potential targets for cancer immunotherapy. This study aimed to assess the value of SIRP alpha and TIGIT as prognostic factors of UPS.Materials and methods The cBio Cancer Genomics Portal was used to analyze mRNA expression data of 50 UPS cases in the Cancer Genome Atlas. We retrieved 49 UPS cases and performed immunohistochemistry (IHC) to detect programmed death ligand 1 (PD-L1), SIRP alpha, CD68, CD163, TIGIT, CD155, and CD8.Results SIRP alpha was positively associated with CD163 (Pearson's r = 0.51, p = 0 .0002) as per open access data and IHC of the cohort (p = 0.002), which revealed that SIRP alpha-positive macrophage infiltration was higher in UPS cells with >= 1% PD-L1 expression than that in UPS cells with