Estrogen receptors alpha and beta and the risk of open-angle glaucoma
Estrogen receptors alpha and beta and the risk of open-angle glaucoma
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DOI：
10.1001/archopht.126.1.110
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
de Jong, Paulus T. V. M.
中科院分区：
文献类型：
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作者：
de Voogd, Simone;Wolfs, Roger C. W.;de Jong, Paulus T. V. M.
目的：探讨雌激素受体α (ESR1)和β (ESR2)基因多态性是否为开角型青光眼（OAG）的危险因素。方法：来自基于人群的鹿特丹研究的55岁及以上的参与者在基线和随访时接受了相同的眼科检查，包括视野筛查和立体视盘摄影。OAG的诊断是基于视盘测量和视野损失的算法。测定了ESR1和ESR2基因的单倍型。结果：在平均随访6.5年之后，3842名参与者中有87名（2.3%）被诊断为OAG。我们没有检测到与ESR1单倍型的任何关联。ESR2单倍型1显示男性发生OAG的风险高出3.6倍（95%置信区间，1.4-9.2）。在女性中，ESR2与OAG发生率无关联。结论：ESR1基因多态性与OAG无关，但ESR2基因多态性似乎会导致男性OAG的风险增加。
Objective: To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG).Methods: Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of OAG was based on an algorithm using optic disc measures and visual field loss. Haplotypes of the ESR1 and ESR2 genes were determined.Results: We diagnosed incident OAG in 87 of 3842 participants (2.3%) at risk after a mean follow-up of 6.5 years. We could not detect any association with ESR1 haplotypes. Haplotype 1 of ESR2 showed a 3.6-fold (95% confidence interval, 1.4-9.2) higher risk of incident OAG in men. In women, no association was found between ESR2 and incident OAG.Conclusion: Polymorphisms in the ESR1 gene are unrelated to OAG, but ESR2 polymorphisms seem to lead to increased risk of OAG in men.