Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from Aspergillus micronesiensis PG-1
Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from Aspergillus micronesiensis PG-1
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Dimericchalasine A 和 Amichalasine D 和 E：来自密克罗尼曲霉 PG-1 的意外细胞松弛素同二聚体和异三聚体
DOI：
10.1021/acs.orglett.0c00141
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Zhang Yonghui
中科院分区：
文献类型：
--
作者：
Wu Zhaodi;Zhang Xiaotian;Chen Chunmei;Zhou Peng;Zhang Mi;Gu Lianghu;Luo Zengwei;Wang Jianping;Tong Qingyi;Zhu Hucheng;Zhang Yonghui
对微小曲霉的研究导致分离出三种前所未有的细胞松弛素（1-3）。Dimericchalasine A（1）是第一个由C-20/C-20′单键融合的细胞松弛素同源二聚体。Amichalasines D（2）和E（3）是一种新型的具有5/6/11/5/5/6/5/12/6/5十环系统的细胞松弛素异源三聚体。通过大量的光谱数据和单晶X-射线衍射确定了它们的结构。提出了1 - 3可能的生物合成途径。
The study ofAspergillus micronesiensisled to the isolation of three unprecedented cytochalasans (1–3). Dimericchalasine A (1) is the first cytochalasan homodimer fused by a C-20/C-20′ single bond. Amichalasines D (2) and E (3) represent a new type of cytochalasan heterotrimer with a decacyclic 5/6/11/5/5/6/5/12/6/5 ring system. Their structures were determined by extensive spectroscopic data and single-crystal X-ray diffraction. The plausible biosynthetic pathways of1–3were proposed.