Blood pressure change in a free-living population-based dietary modification study in Japan
Blood pressure change in a free-living population-based dietary modification study in Japan
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DOI：
10.1097/01.hjh.0000209980.36359.16
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发表时间：
2006-03-01
影响因子：
4.9
通讯作者：
Tsugane, S
中科院分区：
文献类型：
--
作者：
Takahashi, Y;Sasaki, S;Tsugane, S
目的 评估自由生活的健康受试者的饮食干预是否能有效改善血压水平。设计 开放式随机对照试验 在日本东北部的两个乡村设置自由生活的健康受试者。参与者 550 名 40-69 岁的健康志愿者。干预措施 量身定制的饮食教育，鼓励减少钠摄入量，增加维生素 C 和胡萝卜素以及水果和蔬菜的摄入量。主要结果指标 血压、膳食摄入量和尿排泄干预开始后一年收集钠、膳食胡萝卜素和维生素 C 的含量以及水果和蔬菜摄入量数据。 结果 在第一年，干预组和对照组之间钠、膳食维生素 C 和胡萝卜素的膳食 (P = 0.002) 和尿排泄 (P < 0.001) 变化显着差异 (P = 0.003)。干预组的收缩压从 127.9 毫米汞柱降低至 125.2 毫米汞柱（降低 2.7 毫米汞柱；95% 置信区间为 -4.6 至 -0.8），而对照组则从 128.0 毫米汞柱升高至 128.5 毫米汞柱（增加 0.5 毫米汞柱；-1.3 至 2.3）。这一变化具有统计学意义（P = 0.007）。相比之下，各组之间舒张压的变化确实存在显着差异。在受试者中，各组之间的收缩压降低存在显着差异（P = 0.032）。 结论 健康受试者中的中等强度饮食咨询实现了显着的饮食，从而导致收缩压显着降低。
Objective To assess whether dietary intervention in free-living healthy subjects is effective in improving blood pressure levels.Design Open randomised, controlled trialSetting Free-living healthy subjects in two rural villages in north-eastern Japan.Participants Five hundred and fifty healthy volunteers aged 40-69 years.Interventions Tailored dietary education to encourage a decrease in sodium intake and an increase in the intake of vitamin C and carotene, and of fruit and vegetables.Main outcome measures Blood pressure, dietary intake and urinary excretion of sodium, dietary carotene and vitamin C, and fruit and vegetable intake data were collected at 1 year after the start of the intervention.Results During the first year, changes differed significantly between the intervention and control groups for dietary (P = 0.002) and urinary excretion (P < 0.001) of sodium and dietary vitamin C and carotene (P = 0.003). Systolic blood pressure decreased from 127.9 to 125.2 mmHg (2.7 mmHg decrease; 95% confidence interval, -4.6 to -0.8) in the intervention group, whereas it increased from 128.0 to 128.5 mmHg (0.5 increase; -1.3 to 2.3) in the control This change was statistically significant (P = 0.007). In contrast, the change in diastolic blood pressure did significantly differ between the groups. In subjects, a significant difference in systolic blood reduction was seen between the groups (P = 0.032).Conclusion Moderate-intensity dietary counseling in living healthy subjects achieved significant dietary which resulted in a significant decrease in systolic pressure.