KAINIC ACID LESIONS OF THE NUCLEUS ACCUMBENS SELECTIVELY ATTENUATE MORPHINE SELF-ADMINISTRATION
KAINIC ACID LESIONS OF THE NUCLEUS ACCUMBENS SELECTIVELY ATTENUATE MORPHINE SELF-ADMINISTRATION
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DOI：
10.1016/0091-3057(88)90292-4
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发表时间：
1988-01-01
影响因子：
3.6
通讯作者：
SMITH, JE
中科院分区：
文献类型：
--
作者：
DWORKIN, SI;GUERIN, GF;SMITH, JE
红藻氨酸损伤的内在和传出神经元的中央内侧丘脑对反应的影响，同时保持食物，水和吗啡自我管理进行了评估。在多操作基线上训练大鼠对三种不同的杠杆做出反应，这些杠杆导致食物颗粒，水勺的呈现或吗啡的输注。虽然对吗啡水平的反应与剂量（0.83-13.2 mg/输注）有关，但增加药物浓度对损伤前食物和水维持的反应几乎没有影响。双侧注入神经毒素到延髓核减少吗啡自我管理芽没有明显改变食物或水的摄入量。在损伤前的食物灭绝探针产生的药物摄入量的显着增加和水的水平上的响应减少，但神经毒素损伤减弱的食物灭绝引起的水的摄入量减少。 这些数据表明，海人酸损伤的核神经节减少吗啡的增强效果，但不改变食物和水的增强性能。神经元系统可能参与调解环境事件的强化效果进行了讨论。
The influence of kainic acid lesions of intrinsic and efferent neurons of the central medial nucleus accumbens on responding simultaneously maintained by food, water and morphine self-administration was assessed. Rats were trained on a multioperant baseline to respond on three different levers that resulted in either a food pellet, the presentation of a water dipper or an infusion of morphine. While responding on the morphine lever was related to dose (0.83-13.2 mg/infusion), increasing concentrations of the drug had little or no effect on responding maintained by food and water before the lesion. Bilateral infusions of the neurotoxin into the nucleus accumbens decreased morphine self-administration bud did not appreciably alter food or water intake. Food extinction probes before the lesion produced significant increases in drug intake and decreases in responding on the water lever, but the neurotoxin lesion attenuated the food extinction induced decrease in water intake. These data suggested that kainic acid lesions of the nucleus accumbens decrease the reinforcing efficacy of morphine but do not alter the reinforcing properties of food and water. The neuronal systems potentially involved in mediating the reinforcing effects of environmental events are discussed.