Paramyxovirus Glycoproteins and the Membrane Fusion Process.
Paramyxovirus Glycoproteins and the Membrane Fusion Process.
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参氧病毒糖蛋白和膜融合过程。
DOI：
10.1007/s40588-016-0040-8
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发表时间：
2016-09
影响因子：
5.2
通讯作者：
Johnston GP
中科院分区：
文献类型：
--
作者：
Aguilar HC;Henderson BA;Zamora JL;Johnston GP
副粘病毒科包括许多显著影响人类和动物健康的病毒。副粘病毒生命周期中的一个重要步骤是通过病毒-细胞膜融合介导的病毒进入宿主细胞。病毒进入后，感染导致副粘病毒糖蛋白在感染的细胞表面上表达。这可能导致细胞-细胞融合（合胞体形成），通常与发病机制有关。因此，膜融合对于病毒进入和细胞-细胞融合都是必不可少的，并且是治疗开发的有吸引力的靶点。虽然病毒-细胞和细胞-细胞膜融合之间存在重要差异，但许多方面是保守的。副粘病毒通常利用两种包膜糖蛋白来协调膜融合。在这里，我们讨论了这些糖蛋白在膜融合过程的不同步骤中的作用。这些发现可以为副粘病毒属之间的进化关系提供见解，并为预防和治疗发展提供未来的目标。
The family Paramyxoviridae includes many viruses that significantly affect human and animal health. An essential step in the paramyxovirus life cycle is viral entry into host cells, mediated by virus-cell membrane fusion. Upon viral entry, infection results in expression of the paramyxoviral glycoproteins on the infected cell surface. This can lead to cell-cell fusion (syncytia formation), often linked to pathogenesis. Thus membrane fusion is essential for both viral entry and cell-cell fusion and an attractive target for therapeutic development. While there are important differences between viral-cell and cell-cell membrane fusion, many aspects are conserved. The paramyxoviruses generally utilize two envelope glycoproteins to orchestrate membrane fusion. Here, we discuss the roles of these glycoproteins in distinct steps of the membrane fusion process. These findings can offer insights into evolutionary relationships among Paramyxoviridae genera and offer future targets for prophylactic and therapeutic development.