Heterotransplantation of human epidermoid carcinomas to the mouse mutant nude.
Heterotransplantation of human epidermoid carcinomas to the mouse mutant nude.
复制标题
将人表皮样癌异种移植到小鼠突变体裸体中。
DOI：
10.1111/j.1699-0463.1972.tb00340.x
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
J. Rygaard
中科院分区：
文献类型：
--
作者：
C. Povlsen;J. Rygaard
据报道，成功的异种移植的4人表皮样癌，连续移植到小鼠突变体裸。在2例病例中获得了连续传播，迄今为止已传2-5代。肿瘤在小鼠中局部生长，未观察到转移。移植物的组织学和细胞学表现与原人肿瘤完全雅阁。在抑瘤剂的研究中，突变裸鼠被建议作为人类表皮样癌的宿主。
Successful heterotransplantation is reported for 3 out of 4 human epidermoid carcinomas, consecutively transplanted to the mouse mutant nude. Serial transmission was obtained in two cases, so far for 2–5 passages. Tumours grew locally in mice, and no metastases were observed. Histological and cytological appearance of the grafts were in full accord with the original human tumour. The mouse mutant nude is suggested as a host for human epidermoid carcinomas in the study of oncostatic agents.