Passive limb movement: evidence of mechanoreflex sex specificity
Passive limb movement: evidence of mechanoreflex sex specificity
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DOI：
10.1152/ajpheart.00532.2012
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发表时间：
2013-01-01
影响因子：
4.8
通讯作者：
Richardson, Russell S.
中科院分区：
文献类型：
--
作者：
Ives, Stephen J.;McDaniel, John;Richardson, Russell S.
伊韦斯SJ，McDaniel J，Witman MA，Richardson RS.被动肢体运动：机械反射性别特异性的证据。Am J Physiol Heart Circ Physiol 304：H154-H161，2013。首次发表于2012年10月19日; doi：10.1152/ajpheart.00532.2012. -以前的研究已经确定，绝经前妇女表现出衰减的代谢反射，然而，很少有人知道的性别特异性的机械反射。因此，我们试图确定是否存在性别差异的中枢和外周血流动力学反应被动肢体运动。在24名年轻健康受试者（12名女性和12名男性）仰卧被动伸膝3分钟期间，记录了心率、每搏输出量、心输出量（CO）、平均动脉压和股动脉血流量（FBF）。将CO和每搏输出量与体表面积（表示为心脏指数和每搏输出量指数）标准化，消除了基线中心血流动力学的差异，而在外周，基础FBF和股动脉血管传导性在两种性别之间相似。与男性相比，女性对被动肢体运动的中枢血流动力学反应峰值明显减弱（心率：9.0 +/-1 vs. 14.8 +/-2%变化，卒中指数：4.5 +/-0.6 vs. 7.8 +/-1.2%变化，心脏指数：9.6 +/-1 vs. 17.2 +/-2%变化，所有P <0.05），而运动诱导FBF峰值相似增加（167 +/-32 vs. 193 +/-17%变化）和股血管传导性（172 +/-31 vs. 203 +/-16%变化）。此外，男性个体FBF峰值和CO峰值对被动运动的反应之间存在显著的正相关关系，而女性则没有。因此，虽然两种性别表现出相似的运动诱导的充血和外周血管舒张功能，中央血流动力学反应是钝化的女性，这意味着减弱的机械反射。因此，这项研究表明，正如已经认识到的代谢反射，女性的机械反射可能存在性别特异性衰减。
Ives SJ, McDaniel J, Witman MA, Richardson RS. Passive limb movement: evidence of mechanoreflex sex specificity. Am J Physiol Heart Circ Physiol 304: H154-H161, 2013. First published October 19, 2012; doi:10.1152/ajpheart.00532.2012.-Previous studies have determined that premenopausal women exhibit an attenuated metaboreflex; however, little is known about sex specificity of the mechanoreflex. Thus, we sought to determine if sex differences exist in the central and peripheral hemodynamic responses to passive limb movement. Second-by-second measurements of heart rate, stroke volume, cardiac output (CO), mean arterial pressure, and femoral artery blood flow (FBF) were recorded during 3 min of supine passive knee extension in 24 young healthy subjects (12 women and 12 men). Normalization of CO and stroke volume to body surface area, expressed as cardiac index and stroke index, eliminated differences in baseline central hemodynamics, whereas, peripherally, basal FBF and femoral vascular conductance were similar between the sexes. In response to passive limb movement, women displayed significantly attenuated peak central hemodynamic responses compared with men (heart rate: 9.0 +/- 1 vs. 14.8 +/- 2% change, stroke index: 4.5 +/- 0.6 vs. 7.8 +/- 1.2% change, cardiac index: 9.6 +/- 1 vs. 17.2 +/- 2% change, all P < 0.05), whereas movement induced similar increases in peak FBF (167 +/- 32 vs. 193 +/- 17% change) and femoral vascular conductance (172 +/- 31 vs. 203 +/- 16% change) in both sexes (women vs. men, respectively). Additionally, there was a significant positive relationship between individual peak FBF and peak CO response to passive movement in men but not in women. Thus, although both sexes exhibited similar movement-induced hyperemia and peripheral vasodilatory function, the central hemodynamic response was blunted in women, implying an attenuated mechanoreflex. Therefore, this study reveals that, as already recognized with the metaboreflex, there is likely a sex-specific attenuation of the mechanoreflex in women.