Striatal dopamine and the interface between orienting and ingestive functions.
Striatal dopamine and the interface between orienting and ingestive functions.
复制标题
纹状体多巴胺以及定向和摄取功能之间的界面。
DOI：
10.1016/0031-9384(88)90307-1
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发表时间：
1988
影响因子：
2.9
通讯作者：
Schallert,T
中科院分区：
文献类型：
--
作者：
Hall,S;Schallert,T
最近的损伤实验表明，前脑儿茶酚胺能投射参与了一种独特的转换机制，使感觉定向能够在正在进行的摄食行为中发生。单位记录研究表明，只有在动物进食时，纹状体中才有一群神经元对触觉刺激做出反应。这些与感觉相关的细胞可能是将注意力从进食行为转移开的系统的一部分。在本研究中，将6-羟基多巴胺直接注入大鼠的纹状体，以消除该区域的多巴胺能输入。研究人员测试了这些动物在进食时或不进食时对触觉刺激的反应。在不吃东西的试验中，对身体中线两侧的刺激进行定向是快速和可靠的。在进食时，对侧定向从未发生，即使在强烈刺激下也是如此，而同侧定向不受影响。有人认为，脱离进食行为的能力可能重要地依赖于纹状体多巴胺能输入的完整性。
Recent lesion experiments have implicated forebrain catecholaminergic projections in a unique switching mechanism that enables sensory orientation to occur during ongoing feeding behavior. Unit recording studies indicate that there is a population of neurons in the striatum that respond to tactile stimulation only while an animal is eating. These sensory-related cells may serve as part of a system that diverts attention away from ingestive behavior. In the present study, 6-hydroxydopamine was infused directly into the striatum in rats to eliminate the dopaminergic input specifically to this region. The animals were tested for their reactions to tactile stimulation of the vibrissae during or in the absence of eating. During noneating trials, orienting was rapid and reliable to stimuli presented on either side of the body midline. While eating, contralateral orienting never occurred, even when the stimulation was intense, whereas ipsilateral orienting was unaffected. It was suggested that the capacity to disengage from ingestive behavior may depend importantly on the integrity of dopaminergic input to the striatum.