Molecular parasites that evolve longer genomes
Molecular parasites that evolve longer genomes
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DOI：
10.1007/pl00006586
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发表时间：
1999-11-01
影响因子：
3.9
通讯作者：
Ellington, AD
中科院分区：
文献类型：
--
作者：
Marshall, KA;Ellington, AD
利用细胞复制机制或体外扩增反应的分子寄生虫先前已被鉴定。总的来说，这些寄生虫比产生它们的病毒或扩增子要小。这可能是因为较短的基因组可以更快地复制。相比之下，我们已经确定并表征了等温扩增反应的寄生虫，它们比亲本分子长，但复制效率更高。这些结果提出了一个有趣的问题，即复制子的最佳大小是否反映了寄生虫中编码的信息与复制该寄生虫的机器中编码的信息之间的权衡。
Molecular parasites that utilize the replication machinery of cells or of in vitro amplification reactions have previously been characterized. By and large, these parasites have been smaller than the viruses or amplicons that gave rise to them. This is likely because shorter genomes can be replicated more quickly. In contrast, we have identified and characterized parasites of an isothermal amplification reaction that are longer than their parental molecules yet replicate much more efficiently. These results raise interesting questions regarding whether the optimal size of replicators reflects a trade-off between the information encoded in a parasite and the information encoded in the machinery replicating that parasite.