Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis
Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis
复制标题
青春双歧杆菌对慢性应激后焦虑和抑郁样表型的预防作用：肠道菌群-炎症轴的作用
DOI：
10.3389/fnbeh.2019.00126
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发表时间：
2019-06-18
影响因子：
3
通讯作者：
Luo, Huai-Rong
中科院分区：
文献类型：
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作者：
Guo, Ying;Xie, Jian-Ping;Luo, Huai-Rong
压力会扰乱肠道微生物群的平衡，刺激炎症对大脑的机制。此外，压力会导致焦虑和抑郁症。双歧杆菌具有明显的抗炎作用。然而，没有报道集中在抗焦虑和抗抑郁作用的B。与肠道微生物组和炎症有关的肠道菌群在小鼠慢性束缚应激（CRS）。我们发现用B.增加大鼠在旷场中心的停留时间，增加进入高架十字迷宫开放臂的次数和在高架十字迷宫开放臂的停留时间，减少悬尾试验和强迫游泳试验的不动时间。而且，B。乳酸菌增加了粪便中乳酸杆菌的序列比例，而类杆菌减少了序列比例。此外，B.海马组织中IL-1 β、TNF-α、NF-κB p65和Iba 1蛋白表达明显降低，脑源性神经营养因子（BDNF）表达明显升高。结论：B.益生菌与减少炎性细胞因子和重新平衡肠道微生物群有关。
Stress disturbs the balance of the gut microbiota and stimulates inflammation-to-brain mechanisms. Moreover, stress leads to anxiety and depressive disorders. Bifidobacterium adolescentis displays distinct anti-inflammatory effects. However, no report has focused on the anxiolytic and antidepressant effects of B. adolescentis related to the gut microbiome and the inflammation on chronic restraint stress (CRS) in mice. We found that pretreatment with B. adolescentis increased the time spent in the center of the open field apparatus, increased the percentage of entries into the open arms of the elevated plus-maze (EPM) and the percentage of time spent in the open arms of the EPM, and decreased the immobility duration in the tail suspension test as well as the forced swimming test (FST). Moreover, B. adolescentis increased the sequence proportion of Lactobacillus and reduced the sequence proportion of Bacteroides in feces. Furthermore, B. adolescentis markedly reduced the protein expression of interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), p-nuclear factor-kappa B (NF-κB) p65 and Iba1 and elevated brain derived neurotrophic factor (BDNF) expression in the hippocampus. We conclude that the anxiolytic and antidepressant effects of B. adolescentis are related to reducing inflammatory cytokines and rebalancing the gut microbiota.