Network oscillations modulate interictal epileptiform spike rate during human memory
Network oscillations modulate interictal epileptiform spike rate during human memory
复制标题
DOI：
10.1093/brain/awt159
复制
发表时间：
2013-08-01
期刊：
影响因子：
14.5
通讯作者：
Worrell, Gregory A.
中科院分区：
文献类型：
--
作者：
Matsumoto, Joseph Y.;Stead, Matt;Worrell, Gregory A.
11名接受颅内脑电图评估的难治性颞叶癫痫患者参加了视觉识别记忆任务。手动标记发作间期癫痫样棘波，并比较基线和跨越6 s观察期的3个2 s期之间的发生率。在成功的，但不是不成功的，编码的图像有一个显着减少发作间期癫痫样穗率在杏仁核，海马，颞叶皮层。在这些试验中，在最早的编码期间（图像呈现后0-2000 ms），θ、α和β带局部场电位振荡的功率普遍降低，这与出现的局灶性γ频率活动一致。发作间期癫痫样峰频率与谱带功率变化和宽带（4-150 Hz）去极化相关，这预示着发作间期癫痫样峰频率显著降低。场电位功率谱的尖峰触发平均检测到一个突发的低频同步前200毫秒的发作间期癫痫样尖峰，在此期间出现的编码。我们的结论是，癫痫发作间期的癫痫样棘波调制模式的网络振荡活动，伴随着人类的记忆提供了一个新的机制的认知处理，局部场电位动态和癫痫发作间期的癫痫样棘波生成的相互作用的见解。
Eleven patients being evaluated with intracranial electroencephalography for medically resistant temporal lobe epilepsy participated in a visual recognition memory task. Interictal epileptiform spikes were manually marked and their rate of occurrence compared between baseline and three 2 s periods spanning a 6 s viewing period. During successful, but not unsuccessful, encoding of the images there was a significant reduction in interictal epileptiform spike rate in the amygdala, hippocampus, and temporal cortex. During the earliest encoding period (0-2000 ms after image presentation) in these trials there was a widespread decrease in the power of theta, alpha and beta band local field potential oscillations that coincided with emergent focal gamma frequency activity. Interictal epileptiform spike rate correlated with spectral band power changes and broadband (4-150 Hz) desynchronization, which predicted significant reduction in interictal epileptiform spike rate. Spike-triggered averaging of the field potential power spectrum detected a burst of low frequency synchronization 200 ms before the interictal epileptiform spikes that arose during this period of encoding. We conclude that interictal epileptiform spikes are modulated by the patterns of network oscillatory activity that accompany human memory offering a new mechanistic insight into the interplay of cognitive processing, local field potential dynamics and interictal epileptiform spike generation.