Safety of probiotics: comparison of two popular strains
Safety of probiotics: comparison of two popular strains
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DOI：
10.1136/bmj.39010.630799.be
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发表时间：
2006-11-11
影响因子：
105.7
通讯作者：
Kaplan, Michael
中科院分区：
文献类型：
--
作者：
Hammerman, Cathy;Bin-Nun, Alona;Kaplan, Michael
背景人类肠道是来自大约400个物种的1万亿多种活细菌的家园。普通成年人体内的细菌数量大约是细胞数量的20倍。在自然环境中，这些内生细菌与它们的宿主之间形成了一种微妙的共生关系。通过对在无菌环境中饲养的动物的研究，强调了自然菌群对正常肠道发育的重要贡献。这些动物的肠道上皮发育不良，肠道免疫力下降，蠕动功能受损--所有这些都只有在引入正常的肠道菌群后才能改善。2.
BackgroundThe human intestine is home to more than a trillion live bacteria from about 400 species. The average adult body contains about 20 times more bacteria than it does cells. 1 In the natural environment a delicate symbiosis evolves between these endogenous bacteria and their host. The vital contribution of natural flora to normal intestinal development is underscored by studies of animals raised in a germ-free environment. These animals have hypoplastic intestinal epithelia, reduced gut immunity, and impaired peristalsis—all of which improve only when normal gut flora are introduced. 2