Modulation of excitability of human motor cortex (M1) by 1 Hz transcranial magnetic stimulation of the contralateral M1
Modulation of excitability of human motor cortex (M1) by 1 Hz transcranial magnetic stimulation of the contralateral M1
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DOI：
10.1016/s1388-2457(02)00342-5
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发表时间：
2003-01-01
影响因子：
4.7
通讯作者：
Cohen, LG
中科院分区：
文献类型：
--
作者：
Schambra, HM;Sawaki, L;Cohen, LG
目的：以往的研究表明，单脉冲经颅磁刺激（TMS）对一侧运动皮层（M1）有短暂的抑制作用。本研究的目的是验证1 Hz的单脉冲经颅磁刺激（TMS） 30分钟会导致对侧MI的兴奋性持续增加的假设。方法：健康志愿者分别在两种干预之前（基线）和之后的2天进行测试。(a)以静息运动阈值的115%，用1hz TMS刺激M1 30分钟，(b)假性刺激。在未受刺激的运动皮质对侧的手中评估TMS的恢复曲线、捏力和简单反应时间。结果：本研究的主要发现是，与假刺激相比，30分钟的I Hz刺激显著增加了对侧运动皮层的招募曲线（P < 0.005，方差因子分析（ANOVA））。这种变化持续时间超过刺激期至少15分钟，并且在夹紧力或反应时间没有变化的情况下发生。结论：这些结果提高了通过对另一个M1进行1hz的经颅磁刺激来诱导M1的兴奋性持续调节的可能性，这种现象可能反映了半球间相互作用的调节。意义：可以想象，应用于心肌梗死的1赫兹经颅磁刺激可用于调节对侧运动皮层的兴奋性以达到治疗目的。爱尔兰爱思唯尔科学有限公司出版。
Ojective: Previous studies demonstrated that single-pulse transcranial magnetic stimulation (TMS) of one motor cortex (M1) exerts a brief inhibitory effect on the contralateral MI. The purpose of this study was to test the hypothesis that 30 min of 1 Hz TMS of M I will result in a lasting increase in excitability in the contralateral MI.Methods: Healthy volunteers were tested on 2 separate days, before (baseline) and after one of two interventions: (a) stimulation of M1 with 1 Hz TMS for 30 min at 115% of resting motor threshold, and (b) sham stimulation. Recruitment curves to TMS, pinch force, and simple reaction time were assessed in the hand contralateral to the unstimulated motor cortex.Results: The main finding of this study was that 30 min of I Hz significantly increased recruitment curves in the contralateral motor cortex in the real stimulation condition relative to sham (P < 0.005, factorial analysis of variance (ANOVA)). This change outlasted the stimulation period for at least 15 min and occurred in the absence of changes in pinch force or reaction time.Conclusions: These results raise the potential for inducing lasting modulation of excitability in M1 by 1 Hz TMS of the other M1, a phenomenon possibly reflecting modulation of interhemispheric interactions. Significance: It is conceivable that I Hz TMS applied to MI may be used to modulate excitability in the opposite motor cortex for therapeutic purposes. Published by Elsevier Science Ireland Ltd.