Development of a quantitative LC-MS/MS method for the analysis of common propellant powder stabilizers in gunshot residue
Development of a quantitative LC-MS/MS method for the analysis of common propellant powder stabilizers in gunshot residue
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DOI：
10.1111/j.1556-4029.2007.00490.x
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发表时间：
2007-07-01
影响因子：
1.6
通讯作者：
Moucheron, Cecile
中科院分区：
文献类型：
--
作者：
Laza, Desire;Nys, Bart;Moucheron, Cecile
在传统的枪弹残留物扫描电子显微镜/能量色散X射线分析（GSR）中，由于使用无铅弹药或不含重金属的弹药，人们必须越来越频繁地应对该技术的局限性。基于液相色谱串联质谱 (LC-MS/MS) 开发了分析常见推进剂粉末稳定剂有机成分的新方法。创建了一种多反应监测扫描方法，用于筛选标准混合物中存在的 akardite II、乙基中心石、二苯胺、甲基中心石、N-亚硝基二苯胺、2-硝基二苯胺和 4-硝基二苯胺。这些目标化合物中的七分之五可以被选择性地识别出来，并以高精度与其他两种化合物区分开来。通过擦拭收集射手手上的样本，并在分析前进行固相萃取。注射量达到 5 至 115 μg 的检测限。多次射击试验的结果表明，LC-MS/MS 方法适用于检测 9 毫米帕拉弹药发射后收集的样品中的稳定剂。
In traditional scanning electron microscopy/energy dispersive X-ray analysis of gunshot residue (GSR), one has to cope more and more frequently with limitations of this technique due to the use of lead-free ammunition or ammunition lacking heavy metals. New methods for the analysis of the organic components of common propellant powder stabilizers were developed based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). A multiple reactions monitoring scanning method was created for the screening of akardite II, ethylcentralite, diphenylamine, methylcentralite, N-nitrosodiphenylamine, 2-nitrodiphenylamine, and 4-nitrodiphenylamine, present in standards mixtures. Five out of seven of these target compounds can be selectively identified and distinguished from the two others with a high accuracy. Samples from the hands of a shooter were collected by swabbing and underwent solid phase extraction prior to analysis. Detection limits ranging from 5 to 115 mu g injected were achieved. Results from several firing trials show that the LC-MS/MS method is suitable for the detection of stabilizers in samples collected following the firing of 9 mm Para ammunitions.