Cell Adhesion and Spreading Behavior on Vertically Aligned Silicon Nanowire Arrays
Cell Adhesion and Spreading Behavior on Vertically Aligned Silicon Nanowire Arrays
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DOI：
10.1021/am800027d
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发表时间：
2009-01-01
影响因子：
9.5
通讯作者：
Yang, Mengsu
中科院分区：
文献类型：
--
作者：
Qi, Suijian;Yi, Changqing;Yang, Mengsu
在本报告中，我们研究了生物细胞和垂直排列的硅纳米线 (SiNW) 阵列之间的相互作用，并重点关注 SiNW 阵列如何影响细胞粘附和扩散等细胞行为。我们观察到 SiNW 阵列可以支持细胞粘附和生长，并指导细胞粘附和扩散行为。结果还表明，SiNW阵列不仅可以增强细胞与基底的粘附力，还可以限制细胞的铺展。结合细胞形态的扫描电镜图像以及与细胞粘附和扩散过程相关的基因和蛋白质的表达分析结果，我们提出了阵列SiNW如何控制细胞粘附和扩散的机制。 SiNW阵列在引导细胞粘附和扩散行为方面的作用可能有助于细胞微阵列、组织工程支架和分子递送载体的开发，其中强的细胞-基质粘附和减少的细胞-细胞通讯是有益的。
In this report, we studied the interactions between biological cells and vertically aligned silicon nanowire (SiNW) arrays and focused on how SiNW arrays affected cellular behaviors such as cell adhesion and spreading. We observed that SiNW arrays could support cell adhesion and growth and guide cell adhesion and spreading behaviors. The results also showed that SiNW arrays could not only enhance the cell-substrate adhesion force but also restrict cell spreading. Combining the results from scanning electron microscopy images of cell morphology and the expression analysis of genes and proteins related to cell adhesion and spreading process, we proposed a mechanism on how cell adhesion and spreading was controlled by arrayed SiNWs. The effects of SiNW arrays in guiding cell adhesion and spreading behavior might be useful in the development of cell microarrays, tissue engineering scaffolds, and molecule delivery vehicles in which strong cell-substrate adhesion and reduced cell-cell communication were beneficial.