Breast implants and anaplastic large cell lymphomas among females in the California Teachers Study cohort.
Breast implants and anaplastic large cell lymphomas among females in the California Teachers Study cohort.
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加州教师研究队列中女性的乳房植入物和间变性大细胞淋巴瘤。
DOI：
10.1111/bjh.13779
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发表时间：
2016
影响因子：
6.5
通讯作者：
Bernstein,Leslie
中科院分区：
文献类型：
--
作者：
Wang,SophiaS;Deapen,Dennis;Voutsinas,Jenna;LaceyJr,JamesV;Lu,Yani;Ma,Huiyan;Clarke,ChristinaA;Weisenburger,Dennis;Forman,StephenJ;Bernstein,Leslie
临床病例系列报告了乳房植入体和乳房原发性T细胞淋巴瘤的明显共存，特别是间变性大细胞淋巴瘤（ALCL）亚型（Goggil等2015;朱厄尔等2011; Thompson & Prince 2013）。2011年，美国食品药品监督管理局（FDA）报告了“乳房植入体与ALCL发生之间可能存在关联”，并鼓励“对其他研究进行额外评价”（美国食品药品监督管理局，2011年），特别是流行病学数据未得出一致的结果。对5项前瞻性队列研究（包括> 43，000名接受美容乳房植入体的女性，随访时间长达37年）进行的审查未发现ALCL风险过高（Lipworth et al 2008）。来自丹麦队列的约20，000名乳房植入体女性的数据确定了31例淋巴瘤，但没有ALCL（Vase et al 2013）。另一项对> 150，000名植入乳房植入体的女性进行的研究确定了3例乳房ALCL，低于基于癌症登记数据的预期[Spear et al（2010）]。然而，一项嵌套在荷兰基于人群的癌症登记研究中的病例对照研究（1994-2006年病例确定）报告了硅胶乳房植入体与ALCL之间的相关性（比值比[OR]= 18.2，95%置信区间[CI]= 2.1-156.8，基于11例ALCL）。
Clinical case series have reported an apparent coexistence of breast implants and primary T-cell lymphomas of the breast, specifically for the anaplastic large cell lymphoma (ALCL) subtype (Gidengil et al 2015; Jewell et al 2011; Thompson & Prince 2013). In 2011, the Food and Drug Administration (FDA) reported a “possible association between breast implants and the development of ALCL” and encouraged “additional evaluation from other studies”(United States Food and Drug Administration 2011), particularly as epidemiological data have not yielded consistent results. A review of five prospective cohort studies comprising> 43,000 women with cosmetic breast implants followed for up to 37 years found no excess ALCL risk (Lipworth et al 2008). Data from a Danish cohort of approximately 20,000 women with breast implants identified 31 lymphomas, but no ALCLs Vase et al 2013). Another study of> 150,000 women with breast implants identified 3 breast ALCL, which was lower than expected based on cancer registry data [Spear et al (2010)]. However, a case-control study nested within the population-based cancer registry in the Netherlands with case ascertainment from 1994-2006, reported an association between silicone breast implants and ALCL (Odds Ratio [OR]= 18.2, 95% Confidence Interval [CI]= 2.1-156.8, based on 11 ALCLs).