Assessment of the causality of the cadmium--protein relationships in the urine of the general population with reference to the Cadmibel study.
Assessment of the causality of the cadmium--protein relationships in the urine of the general population with reference to the Cadmibel study.
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参考 Cadmibel 研究评估一般人群尿液中镉与蛋白质关系的因果关系。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
R. Lauwerys
中科院分区：
文献类型：
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作者：
Alfred Bernard;H. Roels;N. Thielemans;M. Lierde;R. Lauwerys
工作或一般环境中镉可接受暴露水平的评估通常依赖于对尿镉（身体负荷的指标）与用作肾毒性标志物的蛋白质之间关系的分析。不能先验地排除的一种可能性是，镉和尿中蛋白质之间的关系有时可能是由与镉毒性无关的肾功能障碍引起的。为了验证这一假设，我们测量了114名孕妇的尿液中的镉，其中约20%发生了可逆性肾小管蛋白尿。镉排泄量与年龄显着相关，但与妊娠期或低分子量尿蛋白无关。这表明与镉暴露无关的肾小管功能障碍不一定会增加镉的排泄。因此，这些数据支持最近镉对比利时一般人群肾小管影响的镉研究的结论。
The assessment of acceptable exposure levels to cadmium in the work or general environment frequently relies on the analysis of the relationships between urinary cadmium (an indicator of the body burden) and proteins used as markers of nephrotoxicity. A possibility which cannot be excluded a priori is that the relationships between cadmium and proteins in urine might sometimes result from renal dysfunction unrelated to cadmium toxicity. To test this hypothesis, we have measured cadmium in the urine of 114 pregnant women of whom about 20% had developed a reversible tubular proteinuria. Cadmium excretion was correlated significantly with age but not with duration of pregnancy nor with low molecular weight urinary proteins. This indicates that tubular dysfunction unrelated to cadmium exposure does not necessarily increase cadmium excretion. Hence, these data support the conclusion of the recent Cadmibel Study on the renal tubular effects of cadmium on the general population of Belgium.