A New Pathway for Phthalazine Derivatives via Metal-Free Cyclization of ortho-Alkynylphenyl Ketones and Hydrazine
A New Pathway for Phthalazine Derivatives via Metal-Free Cyclization of ortho-Alkynylphenyl Ketones and Hydrazine
复制标题
通过邻炔基苯基酮和肼的无金属环化生产酞嗪衍生物的新途径
DOI：
10.1002/jhet.1682
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发表时间：
2014-09-01
影响因子：
2.4
通讯作者：
Zhou, Haibing
中科院分区：
文献类型：
--
作者：
Dong, Chune;Liao, Zongquan;Zhou, Haibing
开发了一种二氮杂萘衍生物的一步合成方案。在Et3N存在下，邻炔基苯基酮与肼在温和的反应条件下反应，高收率地方便地制备了一系列二氮杂萘衍生物。通过产物 2i 的 X 射线晶体学分析明确证实了该结构。
A one-step synthetic protocol for phthalazine derivatives has been developed. In the presence of Et3N, a series of phthalazine derivatives were conveniently prepared in high yield by the reaction of ortho-alkynylphenyl ketones and hydrazine under mild reaction conditions. The structure was unambiguously confirmed by X-ray crystallographic analysis of product 2i.