Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics
Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics
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DOI：
10.1016/s0092-8674(00)81341-0
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发表时间：
1996-10-18
期刊：
影响因子：
64.5
通讯作者：
Soriano, P
中科院分区：
文献类型：
--
作者：
Gertler, FB;Niebuhr, K;Soriano, P
果蝇启用所需的轴突结构的正确形成，并在遗传上牵连的信号转导通路介导的果蝇ESTA。我们已经确定了两个小鼠蛋白质，Mena和Evl，这是高度相关的启用以及VASP（血管舒张刺激磷蛋白）。一个保守的结构域的目标Mena到本地化的蛋白质含有特定的脯氨酸丰富的基序。Mena与细胞内病原体单核细胞增生李斯特菌和G-肌动蛋白结合蛋白profilin的表面的关联表明，该分子可能通过促进肌动蛋白聚合而参与细菌运动。在成纤维细胞中表达神经富集的Mena亚型诱导形成异常的富含F-肌动蛋白的副产物，支持这种蛋白在微丝组装和细胞运动中的作用。
Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila Abl. We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain targets Mena to localized proteins containing a specific proline-rich motif. The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement by facilitating actin polymerization. Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility.