The Cost of Quantum Yield
The Cost of Quantum Yield
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DOI：
10.1021/acs.oprd.3c00167
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发表时间：
2023-07-07
影响因子：
3.4
通讯作者：
Swierk，John R.
中科院分区：
文献类型：
--
作者：
Swierk，John R.
光催化反应的量子产率（QY）显著影响其性能，因为低QY的反应需要更强的光源和更长的照明时间才能达到有效的反应速率。不幸的是，在设计用于小分子合成的光催化反应时，QY的重要性经常被忽视，从而导致潜在的成本影响和生产力降低。本研究从文献中考察了各种光化学反应器设计，以估计光子通量和光的产生成本，并研究了QY对成本和生产力的影响。研究结果显示，当qy较低时，成本和生产率将受到严重影响。例如，外部qy低于1%会导致显着的光产生成本和每天不到1 mol产品的最大生产率。此外，该研究强调，高QYs对潜在生产力的影响比高产品产量更大。通过优化QY而不是产品产率，光氧化还原介导的ceralasertib合成的动力学和收益模型证明了每天产生数十万美元额外收入的潜力。总的来说，这项工作强调需要在设计光催化反应时增加对QY的考虑。
The quantum yield (QY) of a photocatalytic reaction significantly influences its performance, as reactions with low QYs require more intense light sources and longer illumination times to achieve efficient reaction rates. Unfortunately, the importance of QY is often overlooked in the design of photocatalytic reactions for small-molecule synthesis, leading to potential cost implications and reduced productivity. This study examines various photochemical reactor designs from the literature to estimate photon flux and light generation costs and investigates the impact of QY on both cost and productivity. The findings reveal substantial penalties in cost and productivity when QYs are low. For instance, external QYs below 1% can result in significant light generation costs and maximum productivities of less than 1 mol of product per day. Moreover, the study highlights that high QYs have a larger effect on potential productivity than high product yields. By optimizing for QY instead of product yield, kinetic and revenue modeling for the photoredox-mediated synthesis of ceralasertib demonstrate the potential for generating hundreds of thousands of dollars in additional revenue per day. Overall, this work emphasizes the need for increased consideration of QY in the design of photocatalytic reactions.