Effect of ventriculo-cisternal perfusion with angiotensin II and indomethacin on the plasma vasopressin concentration.
Effect of ventriculo-cisternal perfusion with angiotensin II and indomethacin on the plasma vasopressin concentration.
复制标题
脑室池灌注血管紧张素 II 和吲哚美辛对血浆加压素浓度的影响。
DOI：
10.1159/000122738
复制
发表时间：
1978
影响因子：
4.1
通讯作者：
R. Shade
中科院分区：
文献类型：
--
作者：
M. Yamamoto;L. Share;R. Shade
In anesthetized dogs, perfusion of the cerebral ventricles with indomethacin (IM), an inhibitor of prostaglandin biosynthesis, at rates of 1.9 or 7.6 microgram/min was without effect on the plasma ADH concentration. Ventriculo-cisternal perfusion with angiotensin II (AII; 19 ng/min) resulted in a 3-fold increase in the plasma ADH concentration within 45 min. When AII and IM were perfused together, the plasma ADH concentration increased only 2-fold, a response which was significantly lower than that obtained with AII alone. Thus, the ability of central AII to stimulate ADH release may depend, at least in part, upon the local release of prostaglandins.
