Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
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喹诺霉素 A1、A2 和 B1，新型 60 元大环内酯类抗生素。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Haruo Seto
中科院分区：
文献类型：
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作者：
Yoichi Hayakawa;M. Matsuoka;Kazuo Shin;Haruo Seto
从小单孢菌（Micromonosporasp.JY16）发酵液中分离得到3种新的大环内酯类抗生素--喹啉霉素A1、A2和B1。喹诺霉素A1抑制多种肿瘤细胞的生长，包括多药耐药细胞。喹诺霉素B1具有类似的细胞毒性，而喹诺霉素A2对这些肿瘤细胞无活性。
Three novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A1 inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B1 was similarly cytotoxic, while quinolidomicin A2 was inactive against these tumor cells.