BMP inhibits neurite growth by a mechanism dependent on LIM-kinase
BMP inhibits neurite growth by a mechanism dependent on LIM-kinase
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DOI：
10.1016/j.bbrc.2007.06.157
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发表时间：
2007-09-07
影响因子：
3.1
通讯作者：
Yamashita, Toshihide
中科院分区：
文献类型：
--
作者：
Matsuura, Iichiro;Endo, Mitsuharu;Yamashita, Toshihide
骨形态发生蛋白（BMP）是一种多功能的生长因子，属于转化生长因子β超家族。BMP调节胚胎发育和器官发生的几个关键方面。在这里，我们证明，BMP-2抑制体外出生后小脑神经元的轴突生长。尽管受体调节的Smad蛋白被BMP-2激活，但这种信号转导对于BMP-2的抑制作用不是必需的。有趣的是，BMP-2激活神经元中的LIM-激酶1，并且LIM-激酶I的显性负性形式消除了BMP-2的作用。因此，BMP-2抑制神经突起生长的LIM-kinase 1依赖的机制，我们的研究结果添加了一个新成员的神经突起生长抑制剂。(c)2007爱思唯尔公司All rights reserved.
Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor-beta superfamily. BMPs regulate several crucial aspects of embryonic development and organogenesis. Here, we demonstrate that BMP-2 inhibits the neurite outgrowth of postnatal cerebellar neurons in vitro. Although receptor-regulated Smad proteins are activated by BMP-2, this signal transduction is not necessary for the inhibitory effect of BMP-2. Interestingly, BMP-2 activates LIM-kinase 1 in the neurons, and the dominant negative form of LIM-kinase I abolishes the effect of BMP-2. Thus, BMP-2 inhibits neurite outgrowth by a LIM-kinase 1-dependent mechanism, and our findings add a new member to the group of neurite growth inhibitors. (c) 2007 Elsevier Inc. All rights reserved.