Targeting the hallmarks of cancer with therapy-induced endoplasmic reticulum (ER) stress.
Targeting the hallmarks of cancer with therapy-induced endoplasmic reticulum (ER) stress.
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DOI：
10.4161/23723556.2014.975089
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发表时间：
2015-01
影响因子：
2.1
通讯作者：
Agostinis P
中科院分区：
文献类型：
--
作者：
Garg AD;Maes H;van Vliet AR;Agostinis P
内质网(ER)是细胞生长、死亡、分化、与免疫细胞或基质细胞相互作用、维持蛋白稳态或内稳态等重要细胞过程的中心，内质网功能与包括癌症在内的多种病理过程有关。最近，一些癌症的主要特征被描绘出来，有望促进抗癌治疗的发展。然而，将内质网应激作为一种广泛针对癌症多个特征的治疗诱导策略很少被讨论，尽管已发现几种初级或继发性内质网应激疗法在癌症患者中显示出积极的临床活性。在本综述中，我们简要回顾了内质网应激生物学领域的主要发现和里程碑，对抗癌治疗具有重要意义。此外，我们全面讨论了可能的策略，通过治疗诱导的内质网应激来靶向癌症的多种特征。
The endoplasmic reticulum (ER) is at the center of a number of vital cellular processes such as cell growth, death, and differentiation, crosstalk with immune or stromal cells, and maintenance of proteostasis or homeostasis, and ER functions have implications for various pathologies including cancer. Recently, a number of major hallmarks of cancer have been delineated that are expected to facilitate the development of anticancer therapies. However, therapeutic induction of ER stress as a strategy to broadly target multiple hallmarks of cancer has been seldom discussed despite the fact that several primary or secondary ER stress-inducing therapies have been found to exhibit positive clinical activity in cancer patients. In the present review we provide a brief historical overview of the major discoveries and milestones in the field of ER stress biology with important implications for anticancer therapy. Furthermore, we comprehensively discuss possible strategies enabling the targeting of multiple hallmarks of cancer with therapy-induced ER stress.