Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles:: implications for drug and gene delivery
Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles:: implications for drug and gene delivery
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DOI：
10.1096/fj.02-0088com
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发表时间：
2002-08-01
期刊：
影响因子：
4.8
通讯作者：
Labhasetwar, V
中科院分区：
文献类型：
--
作者：
Panyam, J;Zhou, WZ;Labhasetwar, V
药物载体的内切溶酶体逃逸对于提高其大分子有效载荷的有效性至关重要，尤其是对溶酶体易降解的有效载荷。目前能够使DNA等大分子通过溶酶体内逃逸的载体受到它们的毒性和仅携带有限类别的治疗剂的能力的限制。在本文中，我们报告了快速(
The endo-lysosomal escape of drug carriers is crucial to enhancing the efficacy of their macromolecular payload, especially the payloads that are susceptible to lysosomal degradation. Current vectors that enable the endo-lysosomal escape of macromolecules such as DNA are limited by their toxicity and by their ability to carry only limited classes of therapeutic agents. In this paper, we report the rapid (