Integrated PET/CT-3: Current applications and future directions
Integrated PET/CT-3: Current applications and future directions
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DOI：
10.1148/radiol.2382041977
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发表时间：
2006-02-01
期刊：
影响因子：
19.7
通讯作者：
Hany, TF
中科院分区：
文献类型：
--
作者：
von Schulthess, GK;Steinert, HC;Hany, TF
在过去的5年中，正电子发射断层扫描（PET）和计算机断层扫描（CT）或PET/CT的组合已经发展，因为PET部分提供的信息与其他成像模式可获得的信息非常不同。然而，PET图像上解剖标志的缺乏使得与解剖横截面数据的一致的“硬件融合”非常有用。临床经验表明了一个单一的方向：将CT添加到PET中首先提高了特异性，但也提高了灵敏度，将PET添加到CT中增加了肿瘤成像的灵敏度和特异性。因此，PET/CT是一种比其单个组件更精确的移动测试，并且可能也比两种模式的图像并排查看更好。增加CT的协同优势在于，PET所需的衰减校正也可以从CT数据中导出。这是通过集成PET和磁共振成像无法获得的优点。这使得PET/CT比单独使用标准衰减校正方法的PET快25%-30%，从而导致更高的患者吞吐量和更舒适的检查，通常持续30分钟或更短。氟脱氧葡萄糖（FDG）PET/CT似乎在许多肿瘤的分期和治疗监测中提供相关信息，包括肺癌，间皮瘤，结直肠癌，淋巴瘤，黑色素瘤等，其他人，前列腺癌是个明显的例外。对于前列腺癌，胆碱衍生物可能变得有用。放射性药物关于FDG PET/CT在肿瘤学中应用的已发表文献仍然有限，但一些设计良好的研究已经证明了PET/CT的益处。
For the past 5 years, combined positron emission tomography (PET) and, computed tomography (CT), or PET/CT, has grown because the PET portion provides information that is very different from that obtainable with other imaging modalities. However, the paucity of anatomic landmarks on PET images makes a consistent "hardware fusion" to anatomic cross-sectional data extremely useful. Clinical experience indicates a single direction: Addition of CT to PET improves specificity foremost, but also sensitivity, and the addition of PET to CT adds sensitivity and specificity in tumor imaging. Thus, PET/CT is a move accurate test than either of its individual components and is probably also better than side-by-side viewing of images from both modalities. The synergistic advantage of adding CT is that the attenuation correction needed for PET can also be derived from the CT data., an advantage not obtainable by integrating PET and magnetic resonance imaging. This makes PET/CT 25%-30% faster than PET alone with standard attenuation-correction methods, leading to higher patient throughput and a more comfortable examination, which typically last 30 minutes or less. Fluorodeoxyglucose (FDG) PET/CT appears to provide relevant information in the staging and therapy monitoring of many tumors, including lung carcinoma, mesothelioma, colorectal cancer, lymphoma, melanoma, and many, others., with the notable exception of prostatic cancer. For prostatic cancer, choline derivatives may become useful. radiopharmaceuticals. The published literature on the applications of FDG PET/CT in oncology is still limited, but several well-designed studies have demonstrated the benefits of PET/CT.