The NIH Human Microbiome Project
The NIH Human Microbiome Project
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DOI：
10.1101/gr.096651.109
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发表时间：
2009-12-01
期刊：
影响因子：
7
通讯作者：
Guyer, Mark
中科院分区：
文献类型：
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作者：
Peterson, Jane;Garges, Susan;Guyer, Mark
人类微生物组计划（HMP）是由美国国立卫生研究院生物医学研究路线图（http://nihroadmap.nih.gov）发起资助的一个多组成部分的社区资源项目。人类微生物组计划的目标是：（1）利用新的高通量技术，通过研究至少250名“正常”志愿者每个人多个身体部位的样本，更全面地描述人类微生物组的特征；（2）通过研究几种不同的疾病状况，确定微生物组的变化与健康/疾病之间是否存在关联；（3）提供标准化的数据资源和新的技术方法，使此类研究能够在科学界广泛开展。此类研究的伦理、法律和社会影响也正在被系统地研究。人类微生物组计划的最终目标是证明通过监测或调控人类微生物组存在改善人类健康的机会。本文描述了这个新项目的历史和实施情况。
The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: ( 1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 "normal'' volunteers; ( 2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and ( 3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.