Patterning of sympathetic preganglionic neuron firing by the central respiratory drive
Patterning of sympathetic preganglionic neuron firing by the central respiratory drive
复制标题
中枢呼吸驱动的交感节前神经元放电模式
DOI：
10.1016/0006-8993(75)90434-5
复制
发表时间：
1975
期刊：
影响因子：
2.9
通讯作者：
C. Polosa
中科院分区：
文献类型：
--
作者：
G. Preiss;F. Kirchner;C. Polosa
交感神经节前或节后神经的集体活动与膈神经的集体活动之间存在着时间关系，这一点已被描述过。这一发现表明呼吸振荡器和交感节前神经元（SPN）之间存在某种形式的耦合。一些偶联是通过完全在CNS内起作用的机制完成的。Gootman 1和Gootman和Cohen 12通过分析迷走神经切断、麻痹、开胸、人工通气的猫的整个内脏神经和膈神经传出活动之间的相位关系，对这些中枢机制进行了定量研究。他们的数据显示，在吸气早期，内脏活动开始增加，在吸气中期达到最大值，之后在吸气期的剩余时间内保持不变或略有下降。在早期呼气阶段活动达到最低限度，之后再次增加，在呼气阶段的中期和晚期达到平台。这些作者认为，这种调制模式可能是由脑干跨相呼吸神经元6和SPN（或其前身神经元）的相互作用引起的。然而，大量的记录不允许制定精确的假设有关的机制，产生所观察到的波形，因为后者可能会出现从一个以上的发射模式的贡献单位的叠加。例如，内脏神经图的吸气峰和呼气峰可能是因为相同的单位在吸气和呼气时都被激发，或者因为一些单位在吸气时被激发，而另一些在呼气时被激发。由于大量记录技术的这些局限性，本工作是古特曼和科恩12以及曼纳德和波洛萨14的工作的逻辑延伸。在后一项研究14的过程中，通过对单个SPN放电的自相关分析，在所研究的一半以上的SPN中检测到呼吸锁定输入的存在。在本研究中，我们记录了单个SPN（或几个单位）的活动，同时膈神经的活动，我们将其用作中枢呼吸周期的指标，在实验条件下，连接呼吸和呼吸的主要反射回路。
The existence of a temporal relationship between the mass activity of sympathetic pre-or postganglionic nerves and that of the phrenic nerve has been described x, a. This finding demonstrates the existence of some form of coupling between the respiratory oscillator and the sympathetic preganglionic neurons (SPNs). Some of the coupling is done by mechanisms acting entirely within the CNS is. Gootman 1 and Gootman and Cohen 12 initiated a quantitative study of these central mechanisms by making an analysis of the phase relationship between the efferent activity of the whole splanchnic nerve and that of the phrenic nerve in vagotomized, paralyzed, thoracotomized, artificially ventilated cats. Their data show that the massed splanchnic activity started to increase during the early inspiratory phase, reached a maximum in midinspiration, after which it remained constant or declined slightly for the remainder of the inspiratory phase. During the early expiratory phase activity reached a minimum, after which it increased again to reach a plateau in the middle and late part of the expiratory phase. These authors suggested that this pattern of modulation could result from an interaction of brain stem phase-spanning respiratory neurons 6 and SPNs (or their antecedent neurons). However, mass recording does not allow the formulation of precise hypotheses concerning the mechanism of generation of the observed wave shape, because the latter may arise from the superposition of more than one firing pattern of the contributing units. For example, the inspiratory and expiratory peaks of the splanchnic neurogram could arise because the same units fire both in inspiration and expiration, or because some units fire in inspiration and others in expiration. On account of these limitations of the mass recording techniques, the present work, which is a logical extension of that of Gootman and Cohen 12 and of Mannard and Polosa 14, was undertaken. In the course of the latter study 14, the presence of a respiration-locked input was detected, by autocorrelation analysis of single SPN firing, in more than half of the SPNs studied. In the present study we have recorded the activity of single SPNs (or of a few units) simultaneously with that of the phrenic nerve, which we used as an index of the central respiratory cycle, in experimental conditions in which the main reflex loops that connect the respiratory to the