DETERMINATION OF ACETYLCHOLINE-RECEPTOR ANTIBODY IN MYASTHENIA-GRAVIS - CLINICAL USEFULNESS AND PATHOGENETIC IMPLICATIONS
DETERMINATION OF ACETYLCHOLINE-RECEPTOR ANTIBODY IN MYASTHENIA-GRAVIS - CLINICAL USEFULNESS AND PATHOGENETIC IMPLICATIONS
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DOI：
10.1136/jnnp.41.5.394
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发表时间：
1978-01-01
影响因子：
11
通讯作者：
PIRSKANEN, R
中科院分区：
文献类型：
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作者：
LEFVERT, AK;BERGSTROM, K;PIRSKANEN, R
抗体胆碱能受体结构被发现在75%的76芬兰和93%的175瑞典重症肌无力患者。抗体的量与疾病的严重程度呈正相关，并且在免疫抑制治疗和胸腺切除术期间减少。胸腺瘤患者的数值较高。在脑脊液中也发现了抗体。两个健康的新生儿的母亲肌无力抗体在1周的生活，尽管没有临床症状。在重症肌无力的早期阶段，2例患者在IgG抗体之前出现IG[免疫球蛋白]M抗体，表明抗体不是疾病的主要原因。
Antibodies to cholinergic receptor structures were found in 75% of 76 Finnish and 93% of 175 Swedish patients with myasthenia gravis. The amount of antibodies showed a positive correlation to the severity of the disease and was reduced during immunosuppressive treatment and by thymectomy. Thymoma patients had high values. The antibody was also found in the CSF. Two healthy newborn babies of myasthenic mothers had antibodies during the 1 weeks of life, in spite of no clinical symptoms. The occurrence of Ig[immunoglobulin]M antibodies before IgG antibodies in 2 patients during the early stages of myasthenia gravis suggests that the antibody is not a primary cause of the disease.