Correlation between neutrophil-to-lymphocyte ratio and kidney dysfunction in undiagnosed hypertensive population from general health checkup
Correlation between neutrophil-to-lymphocyte ratio and kidney dysfunction in undiagnosed hypertensive population from general health checkup
复制标题
体检未确诊高血压人群中性粒细胞/淋巴细胞比值与肾功能障碍的相关性
DOI：
10.1111/jch.13749
复制
发表时间：
2019-12-01
影响因子：
2.8
通讯作者：
Zhang, Yin Hua
中科院分区：
文献类型：
--
作者：
Chen, Chen;Zhao, Hai Yan;Zhang, Yin Hua
近年来，嗜中性粒细胞与淋巴细胞比率（NLR）和单核细胞与淋巴细胞比率（MLR）经常用于评估疾病进展和结局。本研究旨在分析普通人群中未确诊高血压患者在常规健康体检中NLR或MLR与肾功能的关系。分析肝功能以进行比较。从2011年到2016年，有53939名体检者在中国延边大学医院登记健康体检。在拥有完整数据集的15219名参与者中，4997人患有高血压（HTN，SBP/DBP：>= 140/90 mm Hg）。在HTN中，NLR、葡萄糖、脂质（Chol、TG、LDL）、肾脏（CREA、BUN）和肝脏（AST、ALT、GGT、ALB、TBIL）功能参数显著较高。Pearman相关分析显示，仅HTN患者NLR与SBP、CREA呈正相关。在HTN和非HTN中，MLR与CREA相关。在HTN和非HTN中，NLR或MLR与肝功能相关性相似。然后，作者将NLR或MLR分为三分位数（NLR：0-1.7276，1.7276-3，>3; MLR：0-0.1845，0.1845-0.3，>0.3）。在HTN中，NLR >1.7276时与BUN呈正相关，在所有三分位数时与CREA呈正相关。在非HTN中，MLR与高MLR时的CREA和BUN相关。进一步分析显示，年龄或性别不影响HTN中NLR和MLR与肾功能的相关性，但在男性或老年（>65岁）非HTN组中观察到强相关性。这些结果表明，NLR可以作为一个具有成本效益的预测肾脏异常的HTN患者，甚至在一般人群。
Recently, neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are frequently used to evaluate disease progression and outcome. Here, we aim to analyze the associations between NLR or MLR and kidney function in undiagnosed hypertensive individuals from general population during routine health checkup. Liver function was analyzed for comparison. From 2011 to 2016, 53 939 examiners have registered for health checkup in Yanbian University Hospital, Yanbian, China. Among 15 219 participants who have complete datasets, 4997 individuals were hypertensive (HTN, SBP/DBP: >= 140/90 mm Hg). NLR, glucose, lipids (Chol, TG, LDL), kidney (CREA, BUN), and liver (AST, ALT, GGT, ALB, TBIL) functional parameters were significantly higher in HTN. Pearman correlation analysis showed that NLR was positively correlated with SBP and CREA only in HTN. MLR was associated with CREA in both HTN and non-HTN. NLR or MLR was associated with liver functions similarly in HTN and non-HTN. The authors then divided NLR or MLR into tertiles (NLR: 0-1.7276, 1.7276-3, >3; MLR: 0-0.1845, 0.1845-0.3, >0.3). NLR was positively associated with BUN at NLR >1.7276 and with CREA at all tertiles in HTN. MLR was correlated with CREA and BUN at high MLR in non-HTN. Further analysis showed that age or gender did not affect the associations of NLR and MLR with kidney function in HTN, but strong association was observed in male or aged (>65 years old) non-HTN group. These results showed that NLR could be used as a cost-effective predictor of kidney abnormality in HTN patients even in a general population.