Endothelin 2: a key player in ovulation and fertility.
Endothelin 2: a key player in ovulation and fertility.
复制标题
内皮素2：排卵和生育中的关键角色。
DOI：
10.1530/rep-21-0313
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发表时间：
2022-03-05
期刊：
影响因子：
--
通讯作者：
Park CJ
中科院分区：
文献类型：
--
作者：
Ko CJ;Cho YM;Ham E;Cacioppo JA;Park CJ
排卵是卵母细胞从卵巢排出的基本生物学过程，是建立妊娠的重要步骤。了解控制排卵过程的调节机制对于诊断和治疗不孕症的原因，确定避孕目标和开发新的避孕方法至关重要。EDN 2是一种21个氨基酸长的肽，在排卵前由排卵卵泡的颗粒细胞瞬时合成，并通过促进卵泡膜层的肌成纤维细胞的收缩在排卵中起重要作用。本文综述了内皮素系统的组织结构，总结了内皮素系统在卵巢中表达和合成的最新研究结果，阐明了EDN2在调节排卵中的作用，并讨论了EDN2作为避孕的潜在靶点。
Ovulation is the fundamental biological process during which an oocyte is expelled from the ovary, and it is an essential step toward establishing pregnancy. Understanding regulatory mechanisms governing the ovulation process is essential for diagnosing and treating causes of infertility, identifying contraceptive targets, and developing novel contraception methods. EDN2 is a 21-amino acid long peptide that is transiently synthesized by granulosa cells of the ovulatory follicle prior to ovulation and plays an essential role in ovulation via promoting contraction in the myofibroblast cells of the theca layer of the follicle. This review describes the organization of the endothelin system, summarizes recent findings on the expression and synthesis of the endothelin system in the ovary, illustrates the roles that EDN2 plays in regulating ovulation, and discusses EDN2 as a potential target of contraception.