Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents
Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents
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DOI：
10.1039/b823000e
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Mhaske, Santosh B.
中科院分区：
文献类型：
--
作者：
Chong, Hyun-Soon;Song, Hyun A.;Mhaske, Santosh B.
含有潜在铁络合剂NE3TA的胆汁酸-多氨基羧酸盐结合物对HeLa和HT29结肠癌细胞均有明显的细胞毒作用，胆酸-NE3TA结合在有机荧光团上可进入HT29癌细胞。
Bile acid-polyaminocarboxylate conjugates containing NE3TA, a potential iron chelator displayed significant cytotoxicities in both HeLa and HT29 colon cancer cells, and cholic acid-NE3TA attached to an organic fluorophore was shown to enter the HT29 cancer cells.