Chuktabularins A-D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis
Chuktabularins A-D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis
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Chuktabularins A-D，四种新的柠檬苦素类化合物，具有来自 Chukrasia tabularis 茎皮的前所未有的碳骨架
DOI：
10.1021/ol701437h
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发表时间：
2007-08-16
期刊：
影响因子：
5.2
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Zhang, Chuan-Rui;Yang, Sheng-Ping;Yue, Jian-Min
Chuktabularins A-D（1-4）是从Chukrasia tabularis的茎皮中分离得到的4个新的16-norphragmalin型柠檬苦素类化合物，其特征在于前所未有的骨架，在C-15处具有生物合成延伸的C2或C3单元，形成独特的2，7-二氧杂双环[2.2.1]庚烷部分。通过光谱分析和计算机模拟鉴定了它们的结构。推测了1-4的生物合成途径。
Chuktabularins A-D (1-4), four novel 16-norphragmalin-type limonoids that feature unprecedented skeletons with a biosynthetically extended C2 or C3 unit at C-15 forming a unique 2,7-dioxabicyclo[2.2.1]heptane moiety, were isolated from the stem bark of Chukrasia tabularis. Their structures were elucidated by spectroscopic analysis and computer modeling. The biosynthetic pathway of 1-4 was postulated.