Aqueous ionic liquid based ultrasonic assisted extraction of four acetophenones from the Chinese medicinal plant Cynanchum bungei Decne
Aqueous ionic liquid based ultrasonic assisted extraction of four acetophenones from the Chinese medicinal plant Cynanchum bungei Decne
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DOI：
10.1016/j.ultsonch.2012.07.002
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发表时间：
2013-01-01
影响因子：
8.4
通讯作者：
Xu, Ning
中科院分区：
文献类型：
--
作者：
Sun, Yinshi;Liu, Zhengbo;Xu, Ning
建立了一种基于离子液体的超声辅助萃取（ILUAE）方法，用于从白首乌中提取4种苯乙酮类化合物，即4-羟基苯乙酮（1）、2，5-二羟基苯乙酮（2）、白首乌二苯甲酮（3）和2，4-二羟基苯乙酮（4）。研究了3种不同阴离子和烷基链的1-烷基-3-甲基咪唑离子液体的水溶液性质。结果表明，离子液体对苯乙酮类化合物的萃取效果有显著影响。此外，ILUAE，包括几个超声参数，如离子液体浓度，溶剂固比，功率，粒度，温度和提取时间进行了优化。在这些最佳条件下（例如，在0.6M [C4 MIM] BF_4、液固比35：1、功率175 W、粒度60-80目、温度25 ℃、时间50 min条件下，四种苯乙酮的萃取率最高，分别为286.15、21.65、632.58和205.38 μ g/g。通过与传统的热回流提取（HRE）和常规UAE的比较，对所提出的方法进行了评价。结果表明，ILUAE是一种可供选择的提取苯乙酮的方法。bungei。(c)2012爱思唯尔有限公司版权所有。
In this study, an aqueous ionic liquid based ultrasonic assisted extraction (ILUAE) method for the extraction of the four acetophenones, namely 4-hydroxyacetophenone (1), 2,5-dihydroxyacetophenone (2), baishouwubenzophenone (3) and 2,4-dihydroxyacetophenone (4) from the Chinese medicinal plant Cynanchum bungei was developed. Three kinds of aqueous 1-alkyl-3-methylimidazolium ionic liquids with different anion and alkyl chain were investigated. The results indicated that ionic liquids (ILs) showed remarkable effects on the extraction efficiency of acetophenones. In addition, the ILUAE, including several ultrasonic parameters, such as the ILs concentration, solvent to solid ratio, power, particle size, temperature, and extraction time have been optimized. Under these optimal conditions (e.g., with 0.6 M [C4MIM]BF4, solvent to solid ratio of 35:1, power of 175 W, particle size of 60-80 mesh, temperature of 25 degrees C and time of 50 min), this approach gained the highest extraction yields of four acetophenones 286.15, 21.65, 632.58 and 205.38 mu g/g, respectively. The proposed approach has been evaluated by comparison with the conventional heat-reflux extraction (HRE) and regular UAE. The results indicated that ILUAE is an alternative method for extracting acetophenones from C. bungei. (c) 2012 Elsevier B.V. All rights reserved.