Development of Work Sheets to Provide Efficient Pharmaceutical Care during Cancer Chemotherapy and Their Evaluation
Development of Work Sheets to Provide Efficient Pharmaceutical Care during Cancer Chemotherapy and Their Evaluation
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癌症化疗期间提供高效药学服务的工作表的开发及其评估
DOI：
10.5649/jjphcs.32.1
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
H. Ikesue
中科院分区：
文献类型：
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作者：
H. Ikesue
癌症化疗可能会导致许多潜在的严重药物不良反应（ADR），这些不良反应会显著增加发病率和死亡率。正因为如此，药剂师必须负责核实化疗处方，监测ADR和患者教育。然而，这往往是复杂的各种癌症化疗方案使用。此外，医院药剂师的短缺和他们在癌症化疗期间缺乏药学服务的经验使事情变得更加困难，并导致效率低下。因此，药剂师需要创新的工具来帮助他们为这些患者提供药学服务。考虑到这一点，我们最近开发了工作表，用于验证化疗药物的处方订单，监测潜在的ADR，患者教育，并向医务人员提供有关ADR和对策的信息。使用ADR监测表，我们在我院肿瘤病房共监测了671例ADR，其中根据美国国家癌症研究所-常见毒性标准（2.0版），1级毒性311例，2级毒性236例，3级毒性98例，4级毒性26例。在这些ADR中，538例病例（80.2%）为预期病例，发生在预期期间，大多数非预期事件为1级或2级毒性。我们的结论是，我们的工作表是潜在的有用的，在提供有效的药学服务，接受癌症化疗的患者。
Cancer chemotherapy may cause a number of potentially serious adverse drug reactions (ADRs) that contribute significantly to morbidity and mortality. Because of this, pharmacists have to be responsible for verifying chemotherapy prescription orders, ADR monitoring and patient education. However, this is often complicated by the variety of cancer chemotherapy regimens that are used. Also, the shortage of hospital pharmacists and their lack of experience in pharmaceutical care during cancer chemotherapy make things even more difficult and leads to inefficiency. Thus, pharmacists need innovative tools to assist them in providing pharmaceutical care to these patients.With this in mind, we have recently developed work sheets for the verification of prescription orders for chemotherapy agents, monitoring for potential ADRs, patient education, and providing information on ADRs and countermeasures to medical staff. Using the ADR monitoring sheet, we monitored a total of 671 ADRs, comprising 311 of grade 1 toxicity, 236 of grade 2, 98 of grade 3 and 26 of grade 4 according to the National Cancer Institute-Common Toxicity Criteria (version 2.0), in the oncology wards of our hospital. Of these ADRs, 538 cases (80.2%) were anticipated and occurred during the expected period, and most unanticipated events were either grade 1 or 2 toxicity. We concluded that our work sheets are potentially useful in the provision of efficient pharmaceutical care to patients undergoing cancer chemotherapy.